| 1 | Sun Sep 11 | vs Steelers | L20-23 (OT) | 0-1 | .000 | Paycor Stadium · Cincinnati, OH |
| 2 | Sun Sep 18 | atCowboys | L17-20 | 0-2 | .000 | AT&T Stadium · Arlington, TX |
| 3 | Sun Sep 25 | atJets | W27-12 | 1-2 | .333 | MetLife Stadium · East Rutherford, NJ |
| 4 | Thu Sep 29 | vsDolphins | W27-15 | 2-2 | .500 | Paycor Stadium · Cincinnati, OH |
| 5 | Sun Oct 9 | atRavens | L17-19 | 2-3 | .400 | M&T Bank Stadium · Baltimore, MD |
| 6 | Sun Oct 16 | atSaints | W30-26 | 3-3 | .500 | Caesars Superdome · New Orleans, LA |
| 7 | Sun Oct 23 | vsFalcons | W35-17 | 4-3 | .571 | Paycor Stadium · Cincinnati, OH |
| 8 | Mon Oct 31 | atBrowns | L13-32 | 4-4 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 9 | Sun Nov 6 | vsPanthers | W42-21 | 5-4 | .556 | Paycor Stadium · Cincinnati, OH |
| --bye week-- |
| 11 | Sun Nov 20 | atSteelers | W37-30 | 6-4 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sun Nov 27 | atTitans | W20-16 | 7-4 | .636 | Nissan Stadium · Nashville, TN |
| 13 | Sun Dec 4 | vsChiefs | W27-24 | 8-4 | .667 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 11 | vsBrowns | W23-10 | 9-4 | .692 | Paycor Stadium · Cincinnati, OH |
| 15 | Sun Dec 18 | atBuccaneers | W34-23 | 10-4 | .714 | Raymond James Stadium · Tampa, FL |
| 16 | Sat Dec 24 | atPatriots | W22-18 | 11-4 | .733 | Gillette Stadium · Foxborough, MA |
| 18 | Sun Jan 8 | vsRavens | W27-16 | 12-4 | .750 | Paycor Stadium · Cincinnati, OH |
| WC | Sun Jan 15 | vsRavens | W24-17 | 12-4 | .750 | Paycor Stadium · Cincinnati, OH |
| DIV | Sun Jan 22 | atBills | W27-10 | 12-4 | .750 | Highmark Stadium · Orchard Park, NY |
| CONF | Sun Jan 29 | atChiefs | L20-23 | 12-4 | .750 | Arrowhead Stadium · Kansas City, MO |
