| 1 | Sun Sep 10 | at Browns | L3-24 | 0-1 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Sun Sep 17 | vs Ravens | L24-27 | 0-2 | .000 | Paycor Stadium · Cincinnati, OH |
| 3 | Mon Sep 25 | vs Rams | W19-16 | 1-2 | .333 | Paycor Stadium · Cincinnati, OH |
| 4 | Sun Oct 1 | at Titans | L3-27 | 1-3 | .250 | Nissan Stadium · Nashville, TN |
| 5 | Sun Oct 8 | at Cardinals | W34-20 | 2-3 | .400 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 15 | vs Seahawks | W17-13 | 3-3 | .500 | Paycor Stadium · Cincinnati, OH |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 29 | at 49ers | W31-17 | 4-3 | .571 | Levi's® Stadium · Santa Clara, CA |
| 9 | Sun Nov 5 | vs Bills | W24-18 | 5-3 | .625 | Paycor Stadium · Cincinnati, OH |
| 10 | Sun Nov 12 | vs Texans | L27-30 | 5-4 | .556 | Paycor Stadium · Cincinnati, OH |
| 11 | Thu Nov 16 | atRavens | L20-34 | 5-5 | .500 | M&T Bank Stadium · Baltimore, MD |
| 12 | Sun Nov 26 | vs Steelers | L10-16 | 5-6 | .455 | Paycor Stadium · Cincinnati, OH |
| 13 | Mon Dec 4 | at Jaguars | W34-31 (OT) | 6-6 | .500 | TIAA Bank Field · Jacksonville, FL |
| 14 | Sun Dec 10 | vs Colts | W34-14 | 7-6 | .538 | Paycor Stadium · Cincinnati, OH |
| 15 | Sat Dec 16 | vs Vikings | W27-24 (OT) | 8-6 | .571 | Paycor Stadium · Cincinnati, OH |
| 16 | Sat Dec 23 | atSteelers | L11-34 | 8-7 | .533 | Acrisure Stadium · Pittsburgh, PA |
| 17 | Sun Dec 31 | at Chiefs | L17-25 | 8-8 | .500 | Arrowhead Stadium · Kansas City, MO |
| 18 | Sun Jan 7 | vsBrowns | W31-14 | 9-8 | .529 | Paycor Stadium · Cincinnati, OH |
