| 1 | Sun Sep 8 | at Seahawks | L20-21 | 0-1 | .000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 15 | vs49ers | L17-41 | 0-2 | .000 | Paycor Stadium · Cincinnati, OH |
| 3 | Sun Sep 22 | atBills | L17-21 | 0-3 | .000 | Highmark Stadium · Orchard Park, NY |
| 4 | Mon Sep 30 | atSteelers | L3-27 | 0-4 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 5 | Sun Oct 6 | vsCardinals | L23-26 | 0-5 | .000 | Paycor Stadium · Cincinnati, OH |
| 6 | Sun Oct 13 | atRavens | L17-23 | 0-6 | .000 | M&T Bank Stadium · Baltimore, MD |
| 7 | Sun Oct 20 | vsJaguars | L17-27 | 0-7 | .000 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 27 | atRams | L10-24 | 0-8 | .000 | Wembley Stadium · London, England |
| --bye week-- |
| 10 | Sun Nov 10 | vsRavens | L13-49 | 0-9 | .000 | Paycor Stadium · Cincinnati, OH |
| 11 | Sun Nov 17 | atRaiders | L10-17 | 0-10 | .000 | Allegiant Stadium · Las Vegas, NV |
| 12 | Sun Nov 24 | vsSteelers | L10-16 | 0-11 | .000 | Paycor Stadium · Cincinnati, OH |
| 13 | Sun Dec 1 | vsJets | W22-6 | 1-11 | .083 | Paycor Stadium · Cincinnati, OH |
| 14 | Sun Dec 8 | atBrowns | L19-27 | 1-12 | .077 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 15 | vsPatriots | L13-34 | 1-13 | .071 | Paycor Stadium · Cincinnati, OH |
| 16 | Sun Dec 22 | atDolphins | L35-38 (OT) | 1-14 | .067 | Hard Rock Stadium · Miami Gardens, FL |
| 17 | Sun Dec 29 | vsBrowns | W33-23 | 2-14 | .125 | Paycor Stadium · Cincinnati, OH |
