| 1 | Sun Sep 13 | vs Chargers | L13-16 | 0-1 | .000 | Paycor Stadium · Cincinnati, OH |
| 2 | Thu Sep 17 | atBrowns | L30-35 | 0-2 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 3 | Sun Sep 27 | atEagles | T23-23 (OT) | 0-2-1 | .000 | Lincoln Financial Field · Philadelphia, PA |
| 4 | Sun Oct 4 | vsJaguars | W33-25 | 1-2-1 | .333 | Paycor Stadium · Cincinnati, OH |
| 5 | Sun Oct 11 | atRavens | L3-27 | 1-3-1 | .250 | M&T Bank Stadium · Baltimore, MD |
| 6 | Sun Oct 18 | atColts | L27-31 | 1-4-1 | .200 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 25 | vsBrowns | L34-37 | 1-5-1 | .167 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Nov 1 | vsTitans | W31-20 | 2-5-1 | .286 | Paycor Stadium · Cincinnati, OH |
| --bye week-- |
| 10 | Sun Nov 15 | atSteelers | L10-36 | 2-6-1 | .250 | Acrisure Stadium · Pittsburgh, PA |
| 11 | Sun Nov 22 | atCommanders | L9-20 | 2-7-1 | .222 | FedEx Field · North Englewood, MD |
| 12 | Sun Nov 29 | vsGiants | L17-19 | 2-8-1 | .200 | Paycor Stadium · Cincinnati, OH |
| 13 | Sun Dec 6 | atDolphins | L7-19 | 2-9-1 | .182 | Hard Rock Stadium · Miami Gardens, FL |
| 14 | Sun Dec 13 | vsCowboys | L7-30 | 2-10-1 | .167 | Paycor Stadium · Cincinnati, OH |
| 15 | Mon Dec 21 | vsSteelers | W27-17 | 3-10-1 | .231 | Paycor Stadium · Cincinnati, OH |
| 16 | Sun Dec 27 | atTexans | W37-31 | 4-10-1 | .286 | NRG Stadium · Houston, TX |
| 17 | Sun Jan 3 | vsRavens | L3-38 | 4-11-1 | .267 | Paycor Stadium · Cincinnati, OH |
