| 1 | Sun Sep 8 | at Dolphins | L17-20 | 0-1 | .000 | Hard Rock Stadium · Miami Gardens, FL |
| 2 | Sun Sep 15 | vs Browns | L13-18 | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 3 | Mon Sep 23 | at Bills | L10-47 | 0-3 | .000 | Highmark Stadium · Orchard Park, NY |
| 4 | Sun Sep 29 | at Texans | L20-24 | 0-4 | .000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 6 | vs Colts | W37-34 | 1-4 | .200 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 13 | at Bears | L16-35 | 1-5 | .167 | Tottenham Hotspur Stadium · London, England |
| 7 | Sun Oct 20 | vs Patriots | W32-16 | 2-5 | .286 | Wembley Stadium · London, England |
| 8 | Sun Oct 27 | vs Packers | L27-30 | 2-6 | .250 | TIAA Bank Field · Jacksonville, FL |
| 9 | Sun Nov 3 | at Eagles | L23-28 | 2-7 | .222 | Lincoln Financial Field · Philadelphia, PA |
| 10 | Sun Nov 10 | vs Vikings | L7-12 | 2-8 | .200 | TIAA Bank Field · Jacksonville, FL |
| 11 | Sun Nov 17 | at Lions | L6-52 | 2-9 | .182 | Ford Field · Detroit, MI |
| 12 | -- BYE WEEK -- |
| 13 | Sun Dec 1 | vsTexans | L20-23 | 2-10 | .167 | TIAA Bank Field · Jacksonville, FL |
| 14 | Sun Dec 8 | at Titans | W10-6 | 3-10 | .231 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 15 | vs Jets | L25-32 | 3-11 | .214 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 22 | at Raiders | L14-19 | 3-12 | .200 | Allegiant Stadium · Las Vegas, NV |
| 17 | Sun Dec 29 | vsTitans | W20-13 | 4-12 | .250 | TIAA Bank Field · Jacksonville, FL |
| 18 | Sun Jan 5 | atColts | L23-26 (OT) | 4-13 | .235 | Lucas Oil Stadium · Indianapolis, IN |
