| 1 | Sun Sep 12 | at Texans | L21-37 | 0-1 | .000 | NRG Stadium · Houston, TX |
| 2 | Sun Sep 19 | vs Broncos | L13-23 | 0-2 | .000 | TIAA Bank Field · Jacksonville, FL |
| 3 | Sun Sep 26 | vs Cardinals | L19-31 | 0-3 | .000 | TIAA Bank Field · Jacksonville, FL |
| 4 | Thu Sep 30 | at Bengals | L21-24 | 0-4 | .000 | Paycor Stadium · Cincinnati, OH |
| 5 | Sun Oct 10 | vs Titans | L19-37 | 0-5 | .000 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 17 | vs Dolphins | W23-20 | 1-5 | .167 | Tottenham Hotspur Stadium · London, England |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 31 | at Seahawks | L7-31 | 1-6 | .143 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 7 | vs Bills | W9-6 | 2-6 | .250 | TIAA Bank Field · Jacksonville, FL |
| 10 | Sun Nov 14 | at Colts | L17-23 | 2-7 | .222 | Lucas Oil Stadium · Indianapolis, IN |
| 11 | Sun Nov 21 | vs 49ers | L10-30 | 2-8 | .200 | TIAA Bank Field · Jacksonville, FL |
| 12 | Sun Nov 28 | vs Falcons | L14-21 | 2-9 | .182 | TIAA Bank Field · Jacksonville, FL |
| 13 | Sun Dec 5 | at Rams | L7-37 | 2-10 | .167 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 12 | atTitans | L0-20 | 2-11 | .154 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 19 | vsTexans | L16-30 | 2-12 | .143 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 26 | at Jets | L21-26 | 2-13 | .133 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sun Jan 2 | at Patriots | L10-50 | 2-14 | .125 | Gillette Stadium · Foxborough, MA |
| 18 | Sun Jan 9 | vsColts | W26-11 | 3-14 | .176 | TIAA Bank Field · Jacksonville, FL |
