| 1 | Sun Sep 11 | at Commanders | L22-28 | 0-1 | .000 | FedEx Field · North Englewood, MD |
| 2 | Sun Sep 18 | vs Colts | W24-0 | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 3 | Sun Sep 25 | at Chargers | W38-10 | 2-1 | .667 | SoFi Stadium · Inglewood, CA |
| 4 | Sun Oct 2 | at Eagles | L21-29 | 2-2 | .500 | Lincoln Financial Field · Philadelphia, PA |
| 5 | Sun Oct 9 | vs Texans | L6-13 | 2-3 | .400 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 16 | atColts | L27-34 | 2-4 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 23 | vs Giants | L17-23 | 2-5 | .286 | TIAA Bank Field · Jacksonville, FL |
| 8 | Sun Oct 30 | vs Broncos | L17-21 | 2-6 | .250 | Wembley Stadium · London, England |
| 9 | Sun Nov 6 | vs Raiders | W27-20 | 3-6 | .333 | TIAA Bank Field · Jacksonville, FL |
| 10 | Sun Nov 13 | at Chiefs | L17-27 | 3-7 | .300 | Arrowhead Stadium · Kansas City, MO |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 27 | vs Ravens | W28-27 | 4-7 | .364 | TIAA Bank Field · Jacksonville, FL |
| 13 | Sun Dec 4 | at Lions | L14-40 | 4-8 | .333 | Ford Field · Detroit, MI |
| 14 | Sun Dec 11 | at Titans | W36-22 | 5-8 | .385 | Nissan Stadium · Nashville, TN |
| 15 | Sun Dec 18 | vs Cowboys | W40-34 (OT) | 6-8 | .429 | TIAA Bank Field · Jacksonville, FL |
| 16 | Thu Dec 22 | at Jets | W19-3 | 7-8 | .467 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sun Jan 1 | atTexans | W31-3 | 8-8 | .500 | NRG Stadium · Houston, TX |
| WC | Sat Jan 14 | vsChargers | W31-30 | 9-8 | .529 | TIAA Bank Field · Jacksonville, FL |
| DIV | Sat Jan 21 | atChiefs | L20-27 | 9-8 | .529 | Arrowhead Stadium · Kansas City, MO |
