| 1 | Sun Sep 10 | at Colts | W31-21 | 1-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 2 | Sun Sep 17 | vs Chiefs | L9-17 | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 3 | Sun Sep 24 | vs Texans | L17-37 | 1-2 | .333 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Oct 1 | vs Falcons | W23-7 | 2-2 | .500 | Wembley Stadium · London, England |
| 5 | Sun Oct 8 | at Bills | W25-20 | 3-2 | .600 | Tottenham Hotspur Stadium · London, England |
| 6 | Sun Oct 15 | vsColts | W37-20 | 4-2 | .667 | TIAA Bank Field · Jacksonville, FL |
| 7 | Thu Oct 19 | at Saints | W31-24 | 5-2 | .714 | Caesars Superdome · New Orleans, LA |
| 8 | Sun Oct 29 | at Steelers | W20-10 | 6-2 | .750 | Acrisure Stadium · Pittsburgh, PA |
| 9 | -- BYE WEEK -- |
| 10 | Sun Nov 12 | vs 49ers | L3-34 | 6-3 | .667 | TIAA Bank Field · Jacksonville, FL |
| 11 | Sun Nov 19 | vs Titans | W34-14 | 7-3 | .700 | TIAA Bank Field · Jacksonville, FL |
| 12 | Sun Nov 26 | atTexans | W24-21 | 8-3 | .727 | NRG Stadium · Houston, TX |
| 13 | Mon Dec 4 | vs Bengals | L31-34 (OT) | 8-4 | .667 | TIAA Bank Field · Jacksonville, FL |
| 14 | Sun Dec 10 | at Browns | L27-31 | 8-5 | .615 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 17 | vs Ravens | L7-23 | 8-6 | .571 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 24 | at Buccaneers | L12-30 | 8-7 | .533 | Raymond James Stadium · Tampa, FL |
| 17 | Sun Dec 31 | vs Panthers | W26-0 | 9-7 | .563 | TIAA Bank Field · Jacksonville, FL |
| 18 | Sun Jan 7 | atTitans | L20-28 | 9-8 | .529 | Nissan Stadium · Nashville, TN |
