| 1 | Sun Sep 8 | vs Chiefs | L26-40 | 0-1 | .000 | TIAA Bank Field · Jacksonville, FL |
| 2 | Sun Sep 15 | atTexans | L12-13 | 0-2 | .000 | NRG Stadium · Houston, TX |
| 3 | Thu Sep 19 | vsTitans | W20-7 | 1-2 | .333 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Sep 29 | atBroncos | W26-24 | 2-2 | .500 | Empower Field at Mile High · Denver, CO |
| 5 | Sun Oct 6 | atPanthers | L27-34 | 2-3 | .400 | Bank of America Stadium · Charlotte, NC |
| 6 | Sun Oct 13 | vsSaints | L6-13 | 2-4 | .333 | TIAA Bank Field · Jacksonville, FL |
| 7 | Sun Oct 20 | atBengals | W27-17 | 3-4 | .429 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 27 | vsJets | W29-15 | 4-4 | .500 | TIAA Bank Field · Jacksonville, FL |
| 9 | Sun Nov 3 | vsTexans | L3-26 | 4-5 | .444 | Wembley Stadium · London, England |
| --bye week-- |
| 11 | Sun Nov 17 | atColts | L13-33 | 4-6 | .400 | Lucas Oil Stadium · Indianapolis, IN |
| 12 | Sun Nov 24 | atTitans | L20-42 | 4-7 | .364 | Nissan Stadium · Nashville, TN |
| 13 | Sun Dec 1 | vsBuccaneers | L11-28 | 4-8 | .333 | TIAA Bank Field · Jacksonville, FL |
| 14 | Sun Dec 8 | vsChargers | L10-45 | 4-9 | .308 | TIAA Bank Field · Jacksonville, FL |
| 15 | Sun Dec 15 | atRaiders | W20-16 | 5-9 | .357 | Allegiant Stadium · Las Vegas, NV |
| 16 | Sun Dec 22 | atFalcons | L12-24 | 5-10 | .333 | Mercedes-Benz Stadium · Atlanta, GA |
| 17 | Sun Dec 29 | vsColts | W38-20 | 6-10 | .375 | TIAA Bank Field · Jacksonville, FL |
