| 1 | Sun Sep 12 | at Rams | L14-34 | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 19 | vsBengals | W20-17 | 1-1 | .500 | Soldier Field · Chicago, IL |
| 3 | Sun Sep 26 | atBrowns | L6-26 | 1-2 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 3 | vsLions | W24-14 | 2-2 | .500 | Soldier Field · Chicago, IL |
| 5 | Sun Oct 10 | atRaiders | W20-9 | 3-2 | .600 | Allegiant Stadium · Las Vegas, NV |
| 6 | Sun Oct 17 | vsPackers | L14-24 | 3-3 | .500 | Soldier Field · Chicago, IL |
| 7 | Sun Oct 24 | atBuccaneers | L3-38 | 3-4 | .429 | Raymond James Stadium · Tampa, FL |
| 8 | Sun Oct 31 | vs49ers | L22-33 | 3-5 | .375 | Soldier Field · Chicago, IL |
| 9 | Mon Nov 8 | atSteelers | L27-29 | 3-6 | .333 | Acrisure Stadium · Pittsburgh, PA |
| --bye week-- |
| 11 | Sun Nov 21 | vsRavens | L13-16 | 3-7 | .300 | Soldier Field · Chicago, IL |
| 12 | Thu Nov 25 | atLions | W16-14 | 4-7 | .364 | Ford Field · Detroit, MI |
| 13 | Sun Dec 5 | vsCardinals | L22-33 | 4-8 | .333 | Soldier Field · Chicago, IL |
| 14 | Sun Dec 12 | atPackers | L30-45 | 4-9 | .308 | Lambeau Field · Green Bay, WI |
| 15 | Mon Dec 20 | vsVikings | L9-17 | 4-10 | .286 | Soldier Field · Chicago, IL |
| 16 | Sun Dec 26 | atSeahawks | W25-24 | 5-10 | .333 | Lumen Field · Seattle, WA |
| 17 | Sun Jan 2 | vsGiants | W29-3 | 6-10 | .375 | Soldier Field · Chicago, IL |
| 18 | Sun Jan 9 | atVikings | L17-31 | 6-11 | .353 | U.S. Bank Stadium · Minneapolis, MN |
