| 1 | Sun Sep 13 | at Lions | W27-23 | 1-0 | 1.000 | Ford Field · Detroit, MI |
| 2 | Sun Sep 20 | vs Giants | W17-13 | 2-0 | 1.000 | Soldier Field · Chicago, IL |
| 3 | Sun Sep 27 | at Falcons | W30-26 | 3-0 | 1.000 | Mercedes-Benz Stadium · Atlanta, GA |
| 4 | Sun Oct 4 | vs Colts | L11-19 | 3-1 | .750 | Soldier Field · Chicago, IL |
| 5 | Thu Oct 8 | vs Buccaneers | W20-19 | 4-1 | .800 | Soldier Field · Chicago, IL |
| 6 | Sun Oct 18 | at Panthers | W23-16 | 5-1 | .833 | Bank of America Stadium · Charlotte, NC |
| 7 | Mon Oct 26 | at Rams | L10-24 | 5-2 | .714 | SoFi Stadium · Inglewood, CA |
| 8 | Sun Nov 1 | vs Saints | L23-26 (OT) | 5-3 | .625 | Soldier Field · Chicago, IL |
| 9 | Sun Nov 8 | at Titans | L17-24 | 5-4 | .556 | Nissan Stadium · Nashville, TN |
| 10 | Mon Nov 16 | vs Vikings | L13-19 | 5-5 | .500 | Soldier Field · Chicago, IL |
| 11 | -- BYE WEEK -- |
| 12 | Sun Nov 29 | at Packers | L25-41 | 5-6 | .455 | Lambeau Field · Green Bay, WI |
| 13 | Sun Dec 6 | vsLions | L30-34 | 5-7 | .417 | Soldier Field · Chicago, IL |
| 14 | Sun Dec 13 | vs Texans | W36-7 | 6-7 | .462 | Soldier Field · Chicago, IL |
| 15 | Sun Dec 20 | atVikings | W33-27 | 7-7 | .500 | U.S. Bank Stadium · Minneapolis, MN |
| 16 | Sun Dec 27 | at Jaguars | W41-17 | 8-7 | .533 | TIAA Bank Field · Jacksonville, FL |
| 17 | Sun Jan 3 | vsPackers | L16-35 | 8-8 | .500 | Soldier Field · Chicago, IL |
| WC | Sun Jan 10 | atSaints | L9-21 | 8-8 | .500 | Caesars Superdome · New Orleans, LA |
