| 1 | Sun Sep 10 | vs Bengals | W24-3 | 1-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Mon Sep 18 | at Steelers | L22-26 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 24 | vs Titans | W27-3 | 2-1 | .667 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 1 | vs Ravens | L3-28 | 2-2 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 5 | -- BYE WEEK -- |
| 6 | Sun Oct 15 | vs 49ers | W19-17 | 3-2 | .600 | FirstEnergy Stadium · Cleveland, OH |
| 7 | Sun Oct 22 | at Colts | W39-38 | 4-2 | .667 | Lucas Oil Stadium · Indianapolis, IN |
| 8 | Sun Oct 29 | at Seahawks | L20-24 | 4-3 | .571 | Lumen Field · Seattle, WA |
| 9 | Sun Nov 5 | vs Cardinals | W27-0 | 5-3 | .625 | FirstEnergy Stadium · Cleveland, OH |
| 10 | Sun Nov 12 | atRavens | W33-31 | 6-3 | .667 | M&T Bank Stadium · Baltimore, MD |
| 11 | Sun Nov 19 | vsSteelers | W13-10 | 7-3 | .700 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 26 | at Broncos | L12-29 | 7-4 | .636 | Empower Field at Mile High · Denver, CO |
| 13 | Sun Dec 3 | at Rams | L19-36 | 7-5 | .583 | SoFi Stadium · Inglewood, CA |
| 14 | Sun Dec 10 | vs Jaguars | W31-27 | 8-5 | .615 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 17 | vs Bears | W20-17 | 9-5 | .643 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sun Dec 24 | at Texans | W36-22 | 10-5 | .667 | NRG Stadium · Houston, TX |
| 17 | Thu Dec 28 | vs Jets | W37-20 | 11-5 | .688 | FirstEnergy Stadium · Cleveland, OH |
| WC | Sat Jan 13 | atTexans | L14-45 | 11-6 | .647 | NRG Stadium · Houston, TX |
