| 1 | Sun Sep 13 | at Ravens | L6-38 | 0-1 | .000 | M&T Bank Stadium · Baltimore, MD |
| 2 | Thu Sep 17 | vsBengals | W35-30 | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 3 | Sun Sep 27 | vsCommanders | W34-20 | 2-1 | .667 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 4 | atCowboys | W49-38 | 3-1 | .750 | AT&T Stadium · Arlington, TX |
| 5 | Sun Oct 11 | vsColts | W32-23 | 4-1 | .800 | FirstEnergy Stadium · Cleveland, OH |
| 6 | Sun Oct 18 | atSteelers | L7-38 | 4-2 | .667 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Sun Oct 25 | atBengals | W37-34 | 5-2 | .714 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Nov 1 | vsRaiders | L6-16 | 5-3 | .625 | FirstEnergy Stadium · Cleveland, OH |
| --bye week-- |
| 10 | Sun Nov 15 | vsTexans | W10-7 | 6-3 | .667 | FirstEnergy Stadium · Cleveland, OH |
| 11 | Sun Nov 22 | vsEagles | W22-17 | 7-3 | .700 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 29 | atJaguars | W27-25 | 8-3 | .727 | TIAA Bank Field · Jacksonville, FL |
| 13 | Sun Dec 6 | atTitans | W41-35 | 9-3 | .750 | Nissan Stadium · Nashville, TN |
| 14 | Mon Dec 14 | vsRavens | L42-47 | 9-4 | .692 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 20 | atGiants | W20-6 | 10-4 | .714 | MetLife Stadium · East Rutherford, NJ |
| 16 | Sun Dec 27 | atJets | L16-23 | 10-5 | .667 | MetLife Stadium · East Rutherford, NJ |
| 17 | Sun Jan 3 | vsSteelers | W24-22 | 11-5 | .688 | FirstEnergy Stadium · Cleveland, OH |
| WC | Sun Jan 10 | atSteelers | W48-37 | 11-5 | .688 | Acrisure Stadium · Pittsburgh, PA |
| DIV | Sun Jan 17 | atChiefs | L17-22 | 11-5 | .688 | Arrowhead Stadium · Kansas City, MO |
