| 1 | Sun Sep 8 | vs Cowboys | L17-33 | 0-1 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Sun Sep 15 | at Jaguars | W18-13 | 1-1 | .500 | TIAA Bank Field · Jacksonville, FL |
| 3 | Sun Sep 22 | vs Giants | L15-21 | 1-2 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Sep 29 | at Raiders | L16-20 | 1-3 | .250 | Allegiant Stadium · Las Vegas, NV |
| 5 | Sun Oct 6 | at Commanders | L13-34 | 1-4 | .200 | FedEx Field · North Englewood, MD |
| 6 | Sun Oct 13 | at Eagles | L16-20 | 1-5 | .167 | Lincoln Financial Field · Philadelphia, PA |
| 7 | Sun Oct 20 | vs Bengals | L14-21 | 1-6 | .143 | FirstEnergy Stadium · Cleveland, OH |
| 8 | Sun Oct 27 | vs Ravens | W29-24 | 2-6 | .250 | FirstEnergy Stadium · Cleveland, OH |
| 9 | Sun Nov 3 | vs Chargers | L10-27 | 2-7 | .222 | FirstEnergy Stadium · Cleveland, OH |
| 10 | -- BYE WEEK -- |
| 11 | Sun Nov 17 | at Saints | L14-35 | 2-8 | .200 | Caesars Superdome · New Orleans, LA |
| 12 | Thu Nov 21 | vs Steelers | W24-19 | 3-8 | .273 | FirstEnergy Stadium · Cleveland, OH |
| 13 | Mon Dec 2 | at Broncos | L32-41 | 3-9 | .250 | Empower Field at Mile High · Denver, CO |
| 14 | Sun Dec 8 | atSteelers | L14-27 | 3-10 | .231 | Acrisure Stadium · Pittsburgh, PA |
| 15 | Sun Dec 15 | vs Chiefs | L7-21 | 3-11 | .214 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sun Dec 22 | atBengals | L6-24 | 3-12 | .200 | Paycor Stadium · Cincinnati, OH |
| 17 | Sun Dec 29 | vs Dolphins | L3-20 | 3-13 | .188 | FirstEnergy Stadium · Cleveland, OH |
| 18 | Sat Jan 4 | atRavens | L10-35 | 3-14 | .176 | M&T Bank Stadium · Baltimore, MD |
