| 1 | Sun Sep 8 | vs Titans | L13-43 | 0-1 | .000 | FirstEnergy Stadium · Cleveland, OH |
| 2 | Mon Sep 16 | at Jets | W23-3 | 1-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 3 | Sun Sep 22 | vs Rams | L13-20 | 1-2 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Sep 29 | at Ravens | W40-25 | 2-2 | .500 | M&T Bank Stadium · Baltimore, MD |
| 5 | Mon Oct 7 | at 49ers | L3-31 | 2-3 | .400 | Levi's® Stadium · Santa Clara, CA |
| 6 | Sun Oct 13 | vs Seahawks | L28-32 | 2-4 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 27 | at Patriots | L13-27 | 2-5 | .286 | Gillette Stadium · Foxborough, MA |
| 9 | Sun Nov 3 | at Broncos | L19-24 | 2-6 | .250 | Empower Field at Mile High · Denver, CO |
| 10 | Sun Nov 10 | vs Bills | W19-16 | 3-6 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 11 | Thu Nov 14 | vs Steelers | W21-7 | 4-6 | .400 | FirstEnergy Stadium · Cleveland, OH |
| 12 | Sun Nov 24 | vs Dolphins | W41-24 | 5-6 | .455 | FirstEnergy Stadium · Cleveland, OH |
| 13 | Sun Dec 1 | atSteelers | L13-20 | 5-7 | .417 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 8 | vs Bengals | W27-19 | 6-7 | .462 | FirstEnergy Stadium · Cleveland, OH |
| 15 | Sun Dec 15 | at Cardinals | L24-38 | 6-8 | .429 | State Farm Stadium · Glendale, AZ |
| 16 | Sun Dec 22 | vsRavens | L15-31 | 6-9 | .400 | FirstEnergy Stadium · Cleveland, OH |
| 17 | Sun Dec 29 | atBengals | L23-33 | 6-10 | .375 | Paycor Stadium · Cincinnati, OH |
