| 1 | Sun Sep 11 | at Panthers | W26-24 | 1-0 | 1.000 | Bank of America Stadium · Charlotte, NC |
| 2 | Sun Sep 18 | vsJets | L30-31 | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 3 | Thu Sep 22 | vsSteelers | W29-17 | 2-1 | .667 | FirstEnergy Stadium · Cleveland, OH |
| 4 | Sun Oct 2 | atFalcons | L20-23 | 2-2 | .500 | Mercedes-Benz Stadium · Atlanta, GA |
| 5 | Sun Oct 9 | vsChargers | L28-30 | 2-3 | .400 | FirstEnergy Stadium · Cleveland, OH |
| 6 | Sun Oct 16 | vsPatriots | L15-38 | 2-4 | .333 | FirstEnergy Stadium · Cleveland, OH |
| 7 | Sun Oct 23 | atRavens | L20-23 | 2-5 | .286 | M&T Bank Stadium · Baltimore, MD |
| 8 | Mon Oct 31 | vsBengals | W32-13 | 3-5 | .375 | FirstEnergy Stadium · Cleveland, OH |
| --bye week-- |
| 10 | Sun Nov 13 | atDolphins | L17-39 | 3-6 | .333 | Hard Rock Stadium · Miami Gardens, FL |
| 11 | Sun Nov 20 | atBills | L23-31 | 3-7 | .300 | Ford Field · Detroit, MI |
| 12 | Sun Nov 27 | vsBuccaneers | W23-17 (OT) | 4-7 | .364 | FirstEnergy Stadium · Cleveland, OH |
| 13 | Sun Dec 4 | atTexans | W27-14 | 5-7 | .417 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 11 | atBengals | L10-23 | 5-8 | .385 | Paycor Stadium · Cincinnati, OH |
| 15 | Sat Dec 17 | vsRavens | W13-3 | 6-8 | .429 | FirstEnergy Stadium · Cleveland, OH |
| 16 | Sat Dec 24 | vsSaints | L10-17 | 6-9 | .400 | FirstEnergy Stadium · Cleveland, OH |
| 17 | Sun Jan 1 | atCommanders | W24-10 | 7-9 | .438 | FedEx Field · North Englewood, MD |
| 18 | Sun Jan 8 | atSteelers | L14-28 | 7-10 | .412 | Acrisure Stadium · Pittsburgh, PA |
