| 1 | Sun Sep 10 | at Ravens | L9-25 | 0-1 | .000 | M&T Bank Stadium · Baltimore, MD |
| 2 | Sun Sep 17 | vs Colts | L20-31 | 0-2 | .000 | NRG Stadium · Houston, TX |
| 3 | Sun Sep 24 | at Jaguars | W37-17 | 1-2 | .333 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Oct 1 | vs Steelers | W30-6 | 2-2 | .500 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 8 | at Falcons | L19-21 | 2-3 | .400 | Mercedes-Benz Stadium · Atlanta, GA |
| 6 | Sun Oct 15 | vs Saints | W20-13 | 3-3 | .500 | NRG Stadium · Houston, TX |
| 7 | -- BYE WEEK -- |
| 8 | Sun Oct 29 | at Panthers | L13-15 | 3-4 | .429 | Bank of America Stadium · Charlotte, NC |
| 9 | Sun Nov 5 | vs Buccaneers | W39-37 | 4-4 | .500 | NRG Stadium · Houston, TX |
| 10 | Sun Nov 12 | at Bengals | W30-27 | 5-4 | .556 | Paycor Stadium · Cincinnati, OH |
| 11 | Sun Nov 19 | vs Cardinals | W21-16 | 6-4 | .600 | NRG Stadium · Houston, TX |
| 12 | Sun Nov 26 | vsJaguars | L21-24 | 6-5 | .545 | NRG Stadium · Houston, TX |
| 13 | Sun Dec 3 | vs Broncos | W22-17 | 7-5 | .583 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 10 | at Jets | L6-30 | 7-6 | .538 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 17 | at Titans | W19-16 (OT) | 8-6 | .571 | Nissan Stadium · Nashville, TN |
| 16 | Sun Dec 24 | vs Browns | L22-36 | 8-7 | .533 | NRG Stadium · Houston, TX |
| 17 | Sun Dec 31 | vsTitans | W26-3 | 9-7 | .563 | NRG Stadium · Houston, TX |
| 18 | Sat Jan 6 | atColts | W23-19 | 10-7 | .588 | Lucas Oil Stadium · Indianapolis, IN |
| WC | Sat Jan 13 | vsBrowns | W45-14 | 10-7 | .588 | NRG Stadium · Houston, TX |
| DIV | Sat Jan 20 | atRavens | L10-34 | 10-7 | .588 | M&T Bank Stadium · Baltimore, MD |
