| 1 | Sun Sep 12 | vs Jaguars | W37-21 | 1-0 | 1.000 | NRG Stadium · Houston, TX |
| 2 | Sun Sep 19 | at Browns | L21-31 | 1-1 | .500 | FirstEnergy Stadium · Cleveland, OH |
| 3 | Thu Sep 23 | vs Panthers | L9-24 | 1-2 | .333 | NRG Stadium · Houston, TX |
| 4 | Sun Oct 3 | at Bills | L0-40 | 1-3 | .250 | Highmark Stadium · Orchard Park, NY |
| 5 | Sun Oct 10 | vs Patriots | L22-25 | 1-4 | .200 | NRG Stadium · Houston, TX |
| 6 | Sun Oct 17 | at Colts | L3-31 | 1-5 | .167 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 24 | at Cardinals | L5-31 | 1-6 | .143 | State Farm Stadium · Glendale, AZ |
| 8 | Sun Oct 31 | vs Rams | L22-38 | 1-7 | .125 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 7 | at Dolphins | L9-17 | 1-8 | .111 | Hard Rock Stadium · Miami Gardens, FL |
| 10 | -- BYE WEEK -- |
| 11 | Sun Nov 21 | at Titans | W22-13 | 2-8 | .200 | Nissan Stadium · Nashville, TN |
| 12 | Sun Nov 28 | vs Jets | L14-21 | 2-9 | .182 | NRG Stadium · Houston, TX |
| 13 | Sun Dec 5 | vsColts | L0-31 | 2-10 | .167 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 12 | vs Seahawks | L13-33 | 2-11 | .154 | NRG Stadium · Houston, TX |
| 15 | Sun Dec 19 | atJaguars | W30-16 | 3-11 | .214 | TIAA Bank Field · Jacksonville, FL |
| 16 | Sun Dec 26 | vs Chargers | W41-29 | 4-11 | .267 | NRG Stadium · Houston, TX |
| 17 | Sun Jan 2 | at 49ers | L7-23 | 4-12 | .250 | Levi's® Stadium · Santa Clara, CA |
| 18 | Sun Jan 9 | vsTitans | L25-28 | 4-13 | .235 | NRG Stadium · Houston, TX |
