| 4 | Sun Sep 28 | vs Titans | 1:00 PM | 0-3 | .000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 5 | atRavens | 1:00 PM | 1-2 | .333 | M&T Bank Stadium · Baltimore, MD |
| --bye week-- |
| 7 | Mon Oct 20 | atSeahawks | 10:00 PM | 3-1 | .750 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 26 | vs49ers | 1:00 PM | 3-0 | 1.000 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 2 | vsBroncos | 1:00 PM | 1-2 | .333 | NRG Stadium · Houston, TX |
| 10 | Sun Nov 9 | vsJaguars | 1:00 PM | 2-1 | .667 | NRG Stadium · Houston, TX |
| 11 | Sun Nov 16 | atTitans | 1:00 PM | 0-3 | .000 | Nissan Stadium · Nashville, TN |
| 12 | Thu Nov 20 | vsBills | 8:15 PM | 3-0 | 1.000 | NRG Stadium · Houston, TX |
| 13 | Sun Nov 30 | atColts | 1:00 PM | 3-0 | 1.000 | Lucas Oil Stadium · Indianapolis, IN |
| 14 | Sun Dec 7 | atChiefs | 8:20 PM | 1-2 | .333 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 14 | vsCardinals | 1:00 PM | 2-2 | .500 | NRG Stadium · Houston, TX |
| 16 | Sun Dec 21 | vsRaiders | 4:25 PM | 1-2 | .333 | NRG Stadium · Houston, TX |
| 17 | TBD | atChargers | TBD | 3-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 18 | TBD | vsColts | TBD | 3-0 | 1.000 | NRG Stadium · Houston, TX |
