| 1 | Sun Sep 11 | vs Colts | T20-20 (OT) | 0-0-1 | .000 | NRG Stadium · Houston, TX |
| 2 | Sun Sep 18 | atBroncos | L9-16 | 0-1-1 | .250 | Empower Field at Mile High · Denver, CO |
| 3 | Sun Sep 25 | atBears | L20-23 | 0-2-1 | .167 | Soldier Field · Chicago, IL |
| 4 | Sun Oct 2 | vsChargers | L24-34 | 0-3-1 | .125 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 9 | atJaguars | W13-6 | 1-3-1 | .300 | TIAA Bank Field · Jacksonville, FL |
| --bye week-- |
| 7 | Sun Oct 23 | atRaiders | L20-38 | 1-4-1 | .250 | Allegiant Stadium · Las Vegas, NV |
| 8 | Sun Oct 30 | vsTitans | L10-17 | 1-5-1 | .214 | NRG Stadium · Houston, TX |
| 9 | Thu Nov 3 | vsEagles | L17-29 | 1-6-1 | .188 | NRG Stadium · Houston, TX |
| 10 | Sun Nov 13 | atGiants | L16-24 | 1-7-1 | .167 | MetLife Stadium · East Rutherford, NJ |
| 11 | Sun Nov 20 | vsCommanders | L10-23 | 1-8-1 | .150 | NRG Stadium · Houston, TX |
| 12 | Sun Nov 27 | atDolphins | L15-30 | 1-9-1 | .136 | Hard Rock Stadium · Miami Gardens, FL |
| 13 | Sun Dec 4 | vsBrowns | L14-27 | 1-10-1 | .125 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 11 | atCowboys | L23-27 | 1-11-1 | .115 | AT&T Stadium · Arlington, TX |
| 15 | Sun Dec 18 | vsChiefs | L24-30 (OT) | 1-12-1 | .107 | NRG Stadium · Houston, TX |
| 16 | Sat Dec 24 | atTitans | W19-14 | 2-12-1 | .167 | Nissan Stadium · Nashville, TN |
| 17 | Sun Jan 1 | vsJaguars | L3-31 | 2-13-1 | .156 | NRG Stadium · Houston, TX |
| 18 | Sun Jan 8 | atColts | W32-31 | 3-13-1 | .206 | Lucas Oil Stadium · Indianapolis, IN |
