| 1 | Thu Sep 10 | at Chiefs | L20-34 | 0-1 | .000 | Arrowhead Stadium · Kansas City, MO |
| 2 | Sun Sep 20 | vsRavens | L16-33 | 0-2 | .000 | NRG Stadium · Houston, TX |
| 3 | Sun Sep 27 | atSteelers | L21-28 | 0-3 | .000 | Acrisure Stadium · Pittsburgh, PA |
| 4 | Sun Oct 4 | vsVikings | L23-31 | 0-4 | .000 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 11 | vsJaguars | W30-14 | 1-4 | .200 | NRG Stadium · Houston, TX |
| 6 | Sun Oct 18 | atTitans | L36-42 (OT) | 1-5 | .167 | Nissan Stadium · Nashville, TN |
| 7 | Sun Oct 25 | vsPackers | L20-35 | 1-6 | .143 | NRG Stadium · Houston, TX |
| --bye week-- |
| 9 | Sun Nov 8 | atJaguars | W27-25 | 2-6 | .250 | TIAA Bank Field · Jacksonville, FL |
| 10 | Sun Nov 15 | atBrowns | L7-10 | 2-7 | .222 | FirstEnergy Stadium · Cleveland, OH |
| 11 | Sun Nov 22 | vsPatriots | W27-20 | 3-7 | .300 | NRG Stadium · Houston, TX |
| 12 | Thu Nov 26 | atLions | W41-25 | 4-7 | .364 | Ford Field · Detroit, MI |
| 13 | Sun Dec 6 | vsColts | L20-26 | 4-8 | .333 | NRG Stadium · Houston, TX |
| 14 | Sun Dec 13 | atBears | L7-36 | 4-9 | .308 | Soldier Field · Chicago, IL |
| 15 | Sun Dec 20 | atColts | L20-27 | 4-10 | .286 | Lucas Oil Stadium · Indianapolis, IN |
| 16 | Sun Dec 27 | vsBengals | L31-37 | 4-11 | .267 | NRG Stadium · Houston, TX |
| 17 | Sun Jan 3 | vsTitans | L38-41 | 4-12 | .250 | NRG Stadium · Houston, TX |
