| 1 | Sun Sep 8 | vs Giants | W35-17 | 1-0 | 1.000 | AT&T Stadium · Arlington, TX |
| 2 | Sun Sep 15 | atCommanders | W31-21 | 2-0 | 1.000 | FedEx Field · North Englewood, MD |
| 3 | Sun Sep 22 | vsDolphins | W31-6 | 3-0 | 1.000 | AT&T Stadium · Arlington, TX |
| 4 | Sun Sep 29 | atSaints | L10-12 | 3-1 | .750 | Caesars Superdome · New Orleans, LA |
| 5 | Sun Oct 6 | vsPackers | L24-34 | 3-2 | .600 | AT&T Stadium · Arlington, TX |
| 6 | Sun Oct 13 | atJets | L22-24 | 3-3 | .500 | MetLife Stadium · East Rutherford, NJ |
| 7 | Sun Oct 20 | vsEagles | W37-10 | 4-3 | .571 | AT&T Stadium · Arlington, TX |
| --bye week-- |
| 9 | Mon Nov 4 | atGiants | W37-18 | 5-3 | .625 | MetLife Stadium · East Rutherford, NJ |
| 10 | Sun Nov 10 | vsVikings | L24-28 | 5-4 | .556 | AT&T Stadium · Arlington, TX |
| 11 | Sun Nov 17 | atLions | W35-27 | 6-4 | .600 | Ford Field · Detroit, MI |
| 12 | Sun Nov 24 | atPatriots | L9-13 | 6-5 | .545 | Gillette Stadium · Foxborough, MA |
| 13 | Thu Nov 28 | vsBills | L15-26 | 6-6 | .500 | AT&T Stadium · Arlington, TX |
| 14 | Thu Dec 5 | atBears | L24-31 | 6-7 | .462 | Soldier Field · Chicago, IL |
| 15 | Sun Dec 15 | vsRams | W44-21 | 7-7 | .500 | AT&T Stadium · Arlington, TX |
| 16 | Sun Dec 22 | atEagles | L9-17 | 7-8 | .467 | Lincoln Financial Field · Philadelphia, PA |
| 17 | Sun Dec 29 | vsCommanders | W47-16 | 8-8 | .500 | AT&T Stadium · Arlington, TX |
