| 1 | Sun Sep 13 | at Rams | L17-20 | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Sun Sep 20 | vsFalcons | W40-39 | 1-1 | .500 | AT&T Stadium · Arlington, TX |
| 3 | Sun Sep 27 | atSeahawks | L31-38 | 1-2 | .333 | Lumen Field · Seattle, WA |
| 4 | Sun Oct 4 | vsBrowns | L38-49 | 1-3 | .250 | AT&T Stadium · Arlington, TX |
| 5 | Sun Oct 11 | vsGiants | W37-34 | 2-3 | .400 | AT&T Stadium · Arlington, TX |
| 6 | Mon Oct 19 | vsCardinals | L10-38 | 2-4 | .333 | AT&T Stadium · Arlington, TX |
| 7 | Sun Oct 25 | atCommanders | L3-25 | 2-5 | .286 | FedEx Field · North Englewood, MD |
| 8 | Sun Nov 1 | atEagles | L9-23 | 2-6 | .250 | Lincoln Financial Field · Philadelphia, PA |
| 9 | Sun Nov 8 | vsSteelers | L19-24 | 2-7 | .222 | AT&T Stadium · Arlington, TX |
| --bye week-- |
| 11 | Sun Nov 22 | atVikings | W31-28 | 3-7 | .300 | U.S. Bank Stadium · Minneapolis, MN |
| 12 | Thu Nov 26 | vsCommanders | L16-41 | 3-8 | .273 | AT&T Stadium · Arlington, TX |
| 13 | Tue Dec 8 | atRavens | L17-34 | 3-9 | .250 | M&T Bank Stadium · Baltimore, MD |
| 14 | Sun Dec 13 | atBengals | W30-7 | 4-9 | .308 | Paycor Stadium · Cincinnati, OH |
| 15 | Sun Dec 20 | vs49ers | W41-33 | 5-9 | .357 | AT&T Stadium · Arlington, TX |
| 16 | Sun Dec 27 | vsEagles | W37-17 | 6-9 | .400 | AT&T Stadium · Arlington, TX |
| 17 | Sun Jan 3 | atGiants | L19-23 | 6-10 | .375 | MetLife Stadium · East Rutherford, NJ |
