| 1 | Tue Nov 5 | vs Idaho St | W55-48 | 1-0 | 1.000 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 2 | Fri Nov 8 | vsSanta Clara | W81-74 | 2-0 | 1.000 | - | FloSports | Desert Financial Arena · Tempe, AZ |
| 3 | Sun Nov 10 | at6Gonzaga | L80-88 | 2-1 | .667 | - | ESPN | McCarthey Athletic Center · Spokane, WA |
| 4 | Thu Nov 14 | vsGrand Canyon | W87-76 | 3-1 | .750 | - | ESPN2 | Mortgage Matchup Center · Phoenix, AZ |
| 5 | Sun Nov 17 | vsSt Thomas (MN) | W81-66 | 4-1 | .800 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 6 | Wed Nov 20 | vsCal Poly | W93-89 | 5-1 | .833 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 7 | Thu Nov 28 | atNew Mexico | W85-82 | 6-1 | .857 | - | truTV | The Pit · Albuquerque, NM |
| 8 | Fri Nov 29 | vsSaint Mary's | W68-64 | 7-1 | .875 | - | | Desert Financial Arena · Tempe, AZ |
| 9 | Tue Dec 3 | vsSan Diego | W90-53 | 8-1 | .889 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 10 | Sat Dec 14 | at9Florida | L66-83 | 8-2 | .800 | - | SEC Network | State Farm Arena · Atlanta, GA |
| 11 | Sat Dec 21 | atUMass | W78-62 | 9-2 | .818 | - | CBSSN | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Tue Dec 31 | atBYU | L56-76 | 9-3 | .750 | - | ESPN2 | Marriott Center · Provo, UT |
| 13 | Sat Jan 4 | vsColorado | W81-61 | 10-3 | .769 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 14 | Wed Jan 8 | at11Kansas | L55-74 | 10-4 | .714 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 15 | Sat Jan 11 | vsBaylor | L66-72 (OT) | 10-5 | .667 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 16 | Tue Jan 14 | vsUCF | L89-95 | 10-6 | .625 | - | ESPNU | Desert Financial Arena · Tempe, AZ |
| 17 | Sat Jan 18 | atCincinnati | L60-67 | 10-7 | .588 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
| 18 | Tue Jan 21 | at23West Virginia | W65-57 | 11-7 | .611 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 25 | vs3Iowa State | L61-76 | 11-8 | .579 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 20 | Tue Jan 28 | atColorado | W70-68 | 12-8 | .600 | - | ESPN+ | CU Events Center · Boulder, CO |
| 21 | Sat Feb 1 | vsArizona | L72-81 | 12-9 | .571 | - | CBS | Desert Financial Arena · Tempe, AZ |
| 22 | Tue Feb 4 | vsKansas St | L70-71 | 12-10 | .545 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 23 | Sun Feb 9 | atOklahoma St | L73-86 | 12-11 | .522 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Wed Feb 12 | at12Texas Tech | L106-111 (2OT) | 12-12 | .500 | - | CBSSN | United Supermarkets Arena · Lubbock, TX |
| 25 | Sat Feb 15 | vsTCU | L70-74 | 12-13 | .480 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 26 | Tue Feb 18 | vs5Houston | L65-80 | 12-14 | .462 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 27 | Sun Feb 23 | atKansas St | W66-54 | 13-14 | .481 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 28 | Wed Feb 26 | vs25BYU | L81-91 | 13-15 | .464 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 29 | Sat Mar 1 | atUtah | L73-99 | 13-16 | .448 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 30 | Tue Mar 4 | at24Arizona | L100-113 | 13-17 | .433 | - | ESPN | McKale Center · Tucson, AZ |
| 31 | Sat Mar 8 | vs9Texas Tech | L57-85 | 13-18 | .419 | - | ESPNU | Desert Financial Arena · Tempe, AZ |
| 32 | Tue Mar 11 | atKansas St | L66-71 | 13-19 | .406 | - | ESPN+ | T-Mobile Center · Kansas City, MOS |
| 33 | Mon Mar 31 | vsNebraska | L78-86 | 13-20 | .394 | - | FS1 | Desert Financial Arena · Tempe, AZ |
