| 1 | Wed Nov 6 | vs Wake Forest | W77-70 | 1-0 | 1.000 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Sun Nov 10 | at South Florida | W74-60 | 2-0 | 1.000 | - | CBS | Yuengling Center · Tampa, FL |
| 3 | Wed Nov 13 | vs High Point | W59-33 | 3-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 4 | Sat Nov 16 | vs Belmont | L85-100 | 3-1 | .750 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 5 | Wed Nov 20 | vs E Washington | W72-68 | 4-1 | .800 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Sat Nov 23 | vs DePaul | L67-72 | 4-2 | .667 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Wed Nov 27 | vs Saint Louis | L54-64 | 4-3 | .571 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Sat Nov 30 | at Richmond | L44-64 | 4-4 | .500 | - | NBCSN | Robins Center · Richmond, VA |
| 9 | Tue Dec 3 | vs Northwestern | L64-82 | 4-5 | .444 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 10 | Sat Dec 7 | at Notre Dame | W73-72 | 5-5 | .500 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 11 | Tue Dec 10 | vs Albany | W72-51 | 6-5 | .545 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Sun Dec 15 | vs C Connecticut | W74-55 | 7-5 | .583 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Sat Dec 21 | at California | W64-60 | 8-5 | .615 | - | PACN | Haas Pavilion · Berkeley, CA |
| 14 | Tue Dec 31 | at #2Duke | L49-88 | 8-6 | .571 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 15 | Tue Jan 7 | vs #18Virginia | W60-53 | 9-6 | .600 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 16 | Sat Jan 11 | vs Georgia Tech | L52-71 | 9-7 | .563 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Wed Jan 15 | at Syracuse | L50-76 | 9-8 | .529 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 18 | Sun Jan 19 | atWake Forest | L62-80 | 9-9 | .500 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 19 | Wed Jan 22 | at Pitt | L72-74 | 9-10 | .474 | - | | Petersen Events Center · Pittsburgh, PA |
| 20 | Sat Jan 25 | vs Virginia Tech | W61-56 | 10-10 | .500 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 21 | Wed Jan 29 | vs #6Louisville | L69-86 | 10-11 | .476 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Sat Feb 1 | at UNC | W71-70 | 11-11 | .500 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Tue Feb 4 | vs#7Duke | L55-63 | 11-12 | .478 | - | ESPN | Silvio O. Conte Forum · Chestnut Hill, MA |
| 24 | Sat Feb 8 | atVirginia Tech | W77-73 (OT) | 12-12 | .500 | - | | Cassell Coliseum · Blacksburg, VA |
| 25 | Wed Feb 12 | at Miami | L58-85 | 12-13 | .480 | - | | Watsco Center · Coral Gables, FL |
| 26 | Sun Feb 16 | vs NC State | W71-68 | 13-13 | .500 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Wed Feb 19 | atVirginia | L65-78 | 13-14 | .481 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 28 | Sat Feb 22 | vs Clemson | L64-82 | 13-15 | .464 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 29 | Wed Feb 26 | vsNotre Dame | L61-62 | 13-16 | .448 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 30 | Tue Mar 3 | vsSyracuse | L71-84 | 13-17 | .433 | - | ESPN2 | Silvio O. Conte Forum · Chestnut Hill, MA |
| 31 | Sat Mar 7 | at #7Florida St | L62-80 | 13-18 | .419 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 32 | Wed Mar 11 | atNotre Dame | L58-80 | 13-19 | .406 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
