| 1 | Mon Nov 4 | vs The Citadel | W69-60 | - | 1-0 | 1.000 | - | ESPN+ | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Fri Nov 8 | at VCU | L55-80 | - | 1-1 | .500 | - | CBS Sports Network | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Fri Nov 15 | vs Temple | W72-69 | - | 2-1 | .667 | - | ESPN+ | Silvio O. Conte Forum · Chestnut Hill, MA |
| 4 | Tue Nov 19 | vs Loyola MD | W82-61 | - | 3-1 | .750 | - | ESPN+ | Silvio O. Conte Forum · Chestnut Hill, MA |
| 5 | Sun Nov 24 | vs Old Dominion | W82-52 | - | 4-1 | .800 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Mon Nov 25 | vs Missouri St | W76-74 (OT) | - | 5-1 | .833 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Tue Nov 26 | vs Boise St | W63-61 | - | 6-1 | .857 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Fri Nov 29 | vs Dartmouth | L83-88 | - | 6-2 | .750 | - | ESPN+ | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Tue Dec 3 | vs South Carolina | L51-73 | - | 6-3 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 10 | Sat Dec 7 | at Wake Forest | L66-72 | - | 6-4 | .600 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 11 | Sun Dec 15 | vs Stonehill | W73-69 | - | 7-4 | .636 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Sat Dec 21 | vs SMU | L77-103 | - | 7-5 | .583 | - | The CW | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Sat Dec 28 | vs Fairleigh | W78-70 | - | 8-5 | .615 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Wed Jan 1 | vs Miami | W78-68 | - | 9-5 | .643 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 15 | Sat Jan 4 | at Georgia Tech | L64-85 | - | 9-6 | .600 | - | ESPNU | McCamish Pavilion · Atlanta, GA |
| 16 | Sat Jan 11 | vs Syracuse | L71-79 | - | 9-7 | .563 | - | The CW | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Mon Jan 13 | at Notre Dame | L60-78 | - | 9-8 | .529 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 18 | Sat Jan 18 | vs 3Duke | L63-88 | - | 9-9 | .500 | - | ESPN | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Tue Jan 21 | at Virginia | L56-74 | - | 9-10 | .474 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 20 | Sat Jan 25 | at UNC | L96-102 (OT) | - | 9-11 | .450 | - | The CW | Dean E. Smith Center · Chapel Hill, NC |
| 21 | Sat Feb 1 | vs Florida St | W77-76 | - | 10-11 | .476 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Wed Feb 5 | vs Louisville | L58-84 | - | 10-12 | .455 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Sat Feb 8 | at Syracuse | L86-95 (3OT) | - | 10-13 | .435 | - | The CW | JMA Wireless Dome · Syracuse, NY |
| 24 | Wed Feb 12 | vs Notre Dame | L94-97 (2OT) | - | 10-14 | .417 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 25 | Sat Feb 15 | at NC State | L62-70 | - | 10-15 | .400 | - | ACC Network | Lenovo Center · Raleigh, NC |
| 26 | Tue Feb 18 | vs Virginia Tech | W54-36 | - | 11-15 | .423 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Sat Feb 22 | vs Georgia Tech | W69-54 | - | 12-15 | .444 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 28 | Wed Feb 26 | at Stanford | L60-78 | - | 12-16 | .429 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 29 | Sat Mar 1 | at California | L71-82 | - | 12-17 | .414 | - | ESPNU | Haas Pavilion · Berkeley, CA |
| 30 | Wed Mar 5 | vs 11Clemson | L69-78 | - | 12-18 | .400 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 31 | Sat Mar 8 | at Pitt | L67-93 | - | 12-19 | .387 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |