| 1 | Mon Nov 7 | vs Cornell | W79-77 | 1-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Fri Nov 11 | vs Detroit Mercy | W70-66 | 2-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 3 | Mon Nov 14 | vs Maine | L64-69 | 2-1 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 4 | Fri Nov 18 | at George Mason | W71-56 | 3-1 | .750 | - | | EagleBank Arena · Fairfax, VA |
| 5 | Sun Nov 20 | vs Tarleton | L54-70 | 3-2 | .600 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Mon Nov 21 | vs Wyoming | W59-48 | 4-2 | .667 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Sun Nov 27 | vs Rhode Island | W53-49 | 5-2 | .714 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Wed Nov 30 | at Nebraska | L67-88 | 5-3 | .625 | - | ESPNU | Pinnacle Bank Arena · Lincoln, NE |
| 9 | Sat Dec 3 | at #17Duke | L59-75 | 5-4 | .556 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 10 | Tue Dec 6 | vs New Hampshire | L71-74 (OT) | 5-5 | .500 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 11 | Sat Dec 10 | at Villanova | L56-77 | 5-6 | .455 | - | FOX | Finneran Pavilion · Villanova, PA |
| 12 | Tue Dec 13 | vs Stonehill | W63-56 | 6-6 | .500 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Wed Dec 21 | vs #21Virginia Tech | W70-65 (OT) | 7-6 | .538 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Sat Dec 31 | at Syracuse | L65-79 | 7-7 | .500 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 15 | Tue Jan 3 | vs Notre Dame | W70-63 | 8-7 | .533 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 16 | Sat Jan 7 | vs#16Duke | L64-65 | 8-8 | .500 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Wed Jan 11 | at #16Miami | L72-88 | 8-9 | .471 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 18 | Sat Jan 14 | vs Wake Forest | L63-85 | 8-10 | .444 | - | ESPN2 | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Tue Jan 17 | at UNC | L64-72 | 8-11 | .421 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 20 | Sat Jan 21 | atNotre Dame | W84-72 | 9-11 | .450 | - | | Purcell Pavilion · South Bend, IN |
| 21 | Wed Jan 25 | vs Louisville | W75-65 | 10-11 | .476 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Sat Jan 28 | at #7Virginia | L57-76 | 10-12 | .455 | - | | John Paul Jones Arena · Charlottesville, VA |
| 23 | Tue Jan 31 | vs #20Clemson | W62-54 | 11-12 | .478 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 24 | Sat Feb 4 | vsSyracuse | L68-77 | 11-13 | .458 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 25 | Wed Feb 8 | atVirginia Tech | W82-76 | 12-13 | .480 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Sat Feb 11 | vs #22NC State | L62-92 | 12-14 | .462 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Tue Feb 14 | at Pitt | L58-77 | 12-15 | .444 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 28 | Sat Feb 18 | at Florida St | W75-69 | 13-15 | .464 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Wed Feb 22 | vs#6Virginia | W63-48 | 14-15 | .483 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 30 | Tue Feb 28 | atWake Forest | W71-69 | 15-15 | .500 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 31 | Sat Mar 4 | vs Georgia Tech | L65-73 | 15-16 | .484 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 32 | Tue Mar 7 | vsLouisville | W80-62 | 16-16 | .500 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 33 | Wed Mar 8 | atUNC | L61-85 | 16-17 | .485 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
