| 1 | Mon Nov 6 | vs Fairfield | W89-70 | 1-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Fri Nov 10 | at The Citadel | W75-71 | 2-0 | 1.000 | - | | McAlister Field House · Charleston, SC |
| 3 | Wed Nov 15 | vs Richmond | W68-61 | 3-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 4 | Sat Nov 18 | vs Harvard | W73-64 | 4-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 5 | Wed Nov 22 | vs Colorado St | L74-86 | 4-1 | .800 | - | CBS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Thu Nov 23 | at Loyola Chicago | L68-71 | 4-2 | .667 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Wed Nov 29 | at Vanderbilt | W80-62 | 5-2 | .714 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 8 | Sat Dec 2 | vs NC State | L78-84 (OT) | 5-3 | .625 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Tue Dec 5 | vs C Connecticut | W82-68 | 6-3 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 10 | Fri Dec 8 | vs Holy Cross | W95-64 | 7-3 | .700 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 11 | Sun Dec 10 | vs St John's | W86-80 | 8-3 | .727 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Thu Dec 21 | vs Lehigh | W85-69 | 9-3 | .750 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Tue Jan 2 | vs Wake Forest | L78-84 | 9-4 | .692 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Sat Jan 6 | at Georgia Tech | W95-87 | 10-4 | .714 | - | ESPN2 | McCamish Pavilion · Atlanta, GA |
| 15 | Wed Jan 10 | at Syracuse | L59-69 | 10-5 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 16 | Sat Jan 13 | at #21Clemson | L78-89 | 10-6 | .625 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 17 | Mon Jan 15 | vs Notre Dame | W63-59 | 11-6 | .647 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 18 | Sat Jan 20 | vs #4UNC | L66-76 | 11-7 | .611 | - | The CW Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Tue Jan 23 | at Virginia Tech | L71-76 | 11-8 | .579 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 20 | Sat Jan 27 | atNotre Dame | W61-58 | 12-8 | .600 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 21 | Tue Jan 30 | vsSyracuse | W80-75 | 13-8 | .619 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Tue Feb 6 | vs Florida St | L62-63 | 13-9 | .591 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Sat Feb 10 | at #9Duke | L65-80 | 13-10 | .565 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 24 | Tue Feb 13 | vs Louisville | W89-77 | 14-10 | .583 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 25 | Sat Feb 17 | vs Miami | W85-77 | 15-10 | .600 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 26 | Tue Feb 20 | atFlorida St | L76-84 | 15-11 | .577 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 24 | atNC State | L70-81 | 15-12 | .556 | - | ACC Network | PNC Arena · Raleigh, NC |
| 28 | Wed Feb 28 | vs Virginia | L68-72 | 15-13 | .536 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 29 | Sat Mar 2 | vs Pitt | L65-90 | 15-14 | .517 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 30 | Wed Mar 6 | atMiami | W67-57 | 16-14 | .533 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 31 | Sat Mar 9 | atLouisville | W67-61 | 17-14 | .548 | - | The CW Network | KFC Yum! Center · Louisville, KY |
| 32 | Tue Mar 12 | vsMiami | W81-65 | 18-14 | .563 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 33 | Wed Mar 13 | atClemson | W76-55 | 19-14 | .576 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 34 | Thu Mar 14 | atVirginia | L60-66 (OT) | 19-15 | .559 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 35 | Tue Mar 19 | at Providence | W62-57 | 20-15 | .571 | - | ESPNU | Amica Mutual Pavilion · Providence, RI |
| 36 | Sun Mar 24 | at UNLV | L70-79 | 20-16 | .556 | - | ESPNU | Thomas & Mack Center · Las Vegas, NV |
