| 1 | Mon Nov 3 | at FAU | TBD | 18-16 | .529 | - | | FAU Arena · Boca Raton, FL |
| 2 | Thu Nov 6 | vsThe Citadel | TBD | 5-25 | .167 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 3 | Tue Nov 11 | vsC Connecticut | TBD | 25-7 | .781 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 4 | Sat Nov 15 | atTemple | 2:00 PM | 17-15 | .531 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 5 | Tue Nov 18 | vsHampton | TBD | 17-16 | .515 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Fri Nov 21 | vsDavidson | 3:30 PM | 17-16 | .515 | - | ESPN2 | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Wed Nov 26 | vsHarvard | TBD | 12-15 | .444 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Wed Dec 3 | vsLSU | 7:00 PM | 14-18 | .438 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Sat Dec 6 | vsNew Haven | TBD | 0-0 | .000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 10 | Wed Dec 10 | vsUMass | 7:00 PM | 12-20 | .375 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 11 | Mon Dec 22 | vsFairleigh | TBD | 13-20 | .394 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Sun Dec 28 | vsLe Moyne | TBD | 9-23 | .281 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 13 | Sat Jan 3 | atGeorgia Tech | 2:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 14 | Tue Jan 6 | vsNC State | 9:00 PM | 12-19 | .387 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 15 | Sat Jan 10 | at#11Louisville | TBD | 27-8 | .771 | - | | KFC Yum! Center · Louisville, KY |
| 16 | Tue Jan 13 | atClemson | 7:00 PM | 27-7 | .794 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 17 | Sat Jan 17 | vsSyracuse | 2:00 PM | 14-19 | .424 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 18 | Wed Jan 21 | vsPitt | 7:00 PM | 17-15 | .531 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Sat Jan 24 | atNotre Dame | 6:00 PM | 15-18 | .455 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 20 | Sat Jan 31 | vsVirginia | TBD | 15-17 | .469 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 21 | Tue Feb 3 | at#6Duke | 7:00 PM | 35-4 | .897 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 22 | Sat Feb 7 | vsMiami | 2:00 PM | 7-24 | .226 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Wed Feb 11 | vsStanford | 9:00 PM | 21-14 | .600 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 24 | Sat Feb 14 | vsCalifornia | 12:00 PM | 14-19 | .424 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 25 | Tue Feb 17 | atFlorida St | 6:00 PM | 17-15 | .531 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Sat Feb 21 | atSMU | 4:00 PM | 24-11 | .686 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 27 | Tue Feb 24 | vsWake Forest | 7:00 PM | 21-11 | .656 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 28 | Sat Feb 28 | atMiami | 2:00 PM | 7-24 | .226 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 29 | Tue Mar 3 | atVirginia Tech | 9:00 PM | 13-19 | .406 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 30 | Sat Mar 7 | vsNotre Dame | 12:00 PM | 15-18 | .455 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
