| 1 | Tue Nov 9 | vs Dartmouth | W73-57 | 1-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Fri Nov 12 | vs Holy Cross | W85-55 | 2-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 3 | Sun Nov 14 | vs Fairfield | W72-64 | 3-0 | 1.000 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 4 | Wed Nov 17 | at Rhode Island | L49-57 | 3-1 | .750 | - | CBS | Ryan Center · Kingston, RI |
| 5 | Sat Nov 20 | vs Utah | L61-68 | 3-2 | .600 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Sun Nov 21 | atRhode Island | L65-71 | 3-3 | .500 | - | | Ryan Center · Kingston, RI |
| 7 | Fri Nov 26 | vs Columbia | W73-60 | 4-3 | .571 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Mon Nov 29 | vs South Florida | W64-49 | 5-3 | .625 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Fri Dec 3 | vs Notre Dame | W73-57 | 6-3 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 10 | Sat Dec 11 | at Saint Louis | L68-79 | 6-4 | .600 | - | | Chaifetz Arena · St. Louis, MO |
| 11 | Mon Dec 13 | vs Albany | L57-61 | 6-5 | .545 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Wed Dec 22 | at Wake Forest | PPD | 6-5 | .545 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 13 | Wed Dec 29 | vs Florida St | PPD | 13-20 | .394 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Sun Jan 2 | vs UNC | L65-91 | 6-6 | .500 | - | ESPN2 | Silvio O. Conte Forum · Chestnut Hill, MA |
| 15 | Sat Jan 8 | at Pitt | L67-69 | 6-7 | .462 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Wed Jan 12 | vs Georgia Tech | L76-81 | 6-8 | .429 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Sat Jan 15 | at Clemson | W70-68 | 7-8 | .467 | - | | Littlejohn Coliseum · Clemson, SC |
| 18 | Wed Jan 19 | at Louisville | L54-67 | 7-9 | .438 | - | | KFC Yum! Center · Louisville, KY |
| 19 | Sat Jan 22 | vs Virginia Tech | W68-63 | 8-9 | .471 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 20 | Mon Jan 24 | atWake Forest | L57-87 | 8-10 | .444 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 21 | Wed Jan 26 | atUNC | L47-58 | 8-11 | .421 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 22 | Sun Jan 30 | vsPitt | W69-56 | 9-11 | .450 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Tue Feb 1 | at Virginia | L55-67 | 9-12 | .429 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Tue Feb 8 | vs Syracuse | L64-73 | 9-13 | .409 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 25 | Sat Feb 12 | vs #7Duke | L61-72 | 9-14 | .391 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 26 | Wed Feb 16 | atNotre Dame | L95-99 (OT) | 9-15 | .375 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 27 | Sat Feb 19 | atSyracuse | L56-76 | 9-16 | .360 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 28 | Mon Feb 21 | vsFlorida St | W71-55 | 10-16 | .385 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 29 | Wed Feb 23 | at NC State | W69-61 | 11-16 | .407 | - | | PNC Arena · Raleigh, NC |
| 30 | Sat Feb 26 | vsClemson | L60-70 | 11-17 | .393 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 31 | Wed Mar 2 | vs Miami | L70-81 | 11-18 | .379 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 32 | Sat Mar 5 | atGeorgia Tech | L78-82 (OT) | 11-19 | .367 | - | | McCamish Pavilion · Atlanta, GA |
| 33 | Tue Mar 8 | atPitt | W66-46 | 12-19 | .387 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 34 | Wed Mar 9 | atWake Forest | W82-77 (OT) | 13-19 | .406 | - | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 35 | Thu Mar 10 | atMiami | L69-71 (OT) | 13-20 | .394 | - | ESPN2 | Watsco Center · Coral Gables, FL |
