| 1 | Mon Nov 6 | vs TBD | W105-51 | 1-0 | 1.000 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 2 | Sat Nov 11 | at Wofford | L98-99 | 1-1 | .500 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Tue Nov 14 | at Queens | L72-74 | 1-2 | .333 | - | | Curry Arena · Charlotte, NC |
| 4 | Mon Nov 20 | at Iona | W82-68 | 2-2 | .500 | - | | Hynes Athletics Center · New Rochelle, NY |
| 5 | Tue Nov 21 | vs Illinois St | W74-72 | 3-2 | .600 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 6 | Wed Nov 22 | vs Hofstra | L92-97 (OT) | 3-3 | .500 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 7 | Sun Nov 26 | vsTBD | W122-73 | 4-3 | .571 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 8 | Wed Nov 29 | vs Morgan St | W77-59 | 5-3 | .625 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 9 | Sat Dec 2 | at North Florida | W86-79 | 6-3 | .667 | - | | UNF Arena · Jacksonville, FL |
| 10 | Tue Dec 5 | vs W Carolina | W97-71 | 7-3 | .700 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 11 | Fri Dec 8 | vs NC A&T | W75-62 | 8-3 | .727 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 12 | Sat Dec 16 | at Georgia | L58-66 | 8-4 | .667 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 13 | Tue Dec 19 | vs UNC Greensboro | W74-63 | 9-4 | .692 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 14 | Fri Dec 22 | vs Canisius | W78-70 | 10-4 | .714 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 15 | Sat Dec 30 | vs Bellarmine | W90-85 | 11-4 | .733 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 16 | Wed Jan 3 | at Radford | W85-71 | 12-4 | .750 | - | | Donald N. Dedmon Center · Radford, VA |
| 17 | Sat Jan 6 | vs Gardner-Webb | W85-76 | 13-4 | .765 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 18 | Wed Jan 10 | vs UNC Asheville | W84-79 | 14-4 | .778 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 19 | Wed Jan 17 | at Presbyterian | W86-83 | 15-4 | .789 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 20 | Sat Jan 20 | vs Charleston So | W86-79 | 16-4 | .800 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 21 | Wed Jan 24 | at SC Upstate | W78-67 | 17-4 | .810 | - | | G.B. Hodge Center · Spartanburg, SC |
| 22 | Sat Jan 27 | at Winthrop | W83-81 | 18-4 | .818 | - | | Winthrop Coliseum · Rock Hill, SC |
| 23 | Thu Feb 1 | vs Longwood | W93-76 | 19-4 | .826 | - | ESPNU | Nido and Mariana Qubein Arena · High Point, NC |
| 24 | Sat Feb 3 | vsPresbyterian | W78-68 | 20-4 | .833 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 25 | Wed Feb 7 | atUNC Asheville | L81-86 | 20-5 | .800 | - | | Kimmel Arena · Asheville, NC |
| 26 | Sat Feb 10 | atGardner-Webb | W78-62 | 21-5 | .808 | - | | Paul Porter Arena · Boiling Springs, NC |
| 27 | Wed Feb 14 | vsSC Upstate | L81-86 (OT) | 21-6 | .778 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 28 | Sat Feb 17 | vsRadford | W99-74 | 22-6 | .786 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 29 | Sat Feb 24 | atCharleston So | W74-59 | 23-6 | .793 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 30 | Wed Feb 28 | vsWinthrop | W100-96 (OT) | 24-6 | .800 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 31 | Sat Mar 2 | atLongwood | L72-74 | 24-7 | .774 | - | | Willett Hall · Farmville, VA |
| 32 | Fri Mar 8 | vsRadford | W77-63 | 25-7 | .781 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 33 | Sat Mar 9 | vsLongwood | L79-80 (OT) | 25-8 | .758 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 34 | Mon Mar 25 | at Cleveland St | W93-74 | 26-8 | .765 | - | | Wolstein Center · Cleveland, OH |
| 35 | Tue Mar 26 | at Arkansas St | W81-80 | 27-8 | .771 | - | ESPN2 | First National Bank Arena · Jonesboro, AR |
| 36 | Wed Mar 27 | at Seattle U | L67-77 | 27-9 | .750 | - | ESPN2 | Redhawk Center · Seattle, WA |
