| 1 | Mon Nov 3 | vs Furman | W97-71 | 1-0 | 1.000 | - | YouTube | Nido and Mariana Qubein Arena · High Point, NC |
| 2 | Sat Nov 8 | vsTBD | W127-52 | 2-0 | 1.000 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 3 | Tue Nov 11 | vsJacksonville | W85-64 | 3-0 | 1.000 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 4 | Fri Nov 14 | atUAB | L74-91 | 3-1 | .750 | - | ESPN+ | Bartow Arena · Birmingham, AL |
| 5 | Mon Nov 17 | vsCanisius | W93-50 | 4-1 | .800 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 6 | Thu Nov 20 | atUIC | W90-80 | 5-1 | .833 | - | | Credit Union 1 Arena · Chicago, IL |
| 7 | Sat Nov 22 | vsIncarnate Word | W91-80 | 6-1 | .857 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 8 | Sat Nov 29 | vsW Carolina | W93-73 | 7-1 | .875 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 9 | Wed Dec 3 | vsS Illinois | L84-86 | 7-2 | .778 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 10 | Fri Dec 5 | vsNJIT | W89-72 | 8-2 | .800 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 11 | Sun Dec 14 | atAppalachian St | L78-86 (OT) | 8-3 | .727 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
| 12 | Tue Dec 16 | vsTBD | W129-47 | 9-3 | .750 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 13 | Fri Dec 19 | vsLa Salle | W84-72 | 10-3 | .769 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 14 | Mon Dec 22 | vsBryant | W93-47 | 11-3 | .786 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 15 | Sun Dec 28 | vsTBD | W123-64 | 12-3 | .800 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 16 | Wed Dec 31 | atUNC Asheville | W87-69 | 13-3 | .813 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 17 | Sat Jan 3 | vsLongwood | W80-67 | 14-3 | .824 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 18 | Wed Jan 7 | vsGardner-Webb | W104-49 | 15-3 | .833 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 19 | Sat Jan 10 | atCharleston So | W84-82 (OT) | 16-3 | .842 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Wed Jan 14 | atWinthrop | L75-92 | 16-4 | .800 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 17 | vsSC Upstate | W89-69 | 17-4 | .810 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 22 | Fri Jan 23 | atRadford | W93-83 | 18-4 | .818 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 23 | Thu Jan 29 | vsPresbyterian | W84-81 | 19-4 | .826 | - | ESPNU | Nido and Mariana Qubein Arena · High Point, NC |
| 24 | Sat Jan 31 | atLongwood | W71-59 | 20-4 | .833 | - | ESPN+ | Willett Hall · Farmville, VA |
| 25 | Wed Feb 4 | vsCharleston So | W80-55 | 21-4 | .840 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 26 | Sat Feb 7 | vsRadford | W86-77 | 22-4 | .846 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 27 | Thu Feb 12 | atSC Upstate | W95-70 | 23-4 | .852 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 28 | Sat Feb 14 | atGardner-Webb | W112-87 | 24-4 | .857 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 29 | Thu Feb 19 | vsUNC Asheville | W74-48 | 25-4 | .862 | - | ESPNU | Nido and Mariana Qubein Arena · High Point, NC |
| 30 | Sat Feb 21 | vsWinthrop | W89-87 | 26-4 | .867 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 31 | Thu Feb 26 | atPresbyterian | W79-73 | 27-4 | .871 | - | ESPNU | Ross E. Templeton P.E. Center · Clinton, SC |
| 32 | Fri Mar 6 | vsGardner-Webb | W81-59 | 28-4 | .875 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 33 | Sat Mar 7 | vsUNC Asheville | W75-71 | 29-4 | .879 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 34 | Sun Mar 8 | vsWinthrop | W91-76 | 30-4 | .882 | - | ESPN2 | Freedom Hall Civic Center · Johnson City, TN |
| R1 | Thu Mar 19 | at5Wisconsin | W83-82 | 31-4 | .886 | #12 | TBS | Moda Center · Portland, OR |
| R2 | Sat Mar 21 | at4Arkansas | L88-94 | 31-5 | .861 | #12 | truTV | Moda Center · Portland, OR |
