| 1 | Sun Nov 29 | vs AR-Pine Bluff | W80-63 | 1-0 | 1.000 | - | | James H. Hilton Coliseum · Ames, IA |
| 2 | Wed Dec 2 | vs S Dakota St | L68-71 | 1-1 | .500 | - | | James H. Hilton Coliseum · Ames, IA |
| 4 | Fri Dec 11 | at #3Iowa | L77-105 | 1-2 | .333 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Tue Dec 15 | vs Kansas St | L65-74 | 1-3 | .250 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 6 | Fri Dec 18 | at #8West Virginia | L65-70 | 1-4 | .200 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 7 | Sun Dec 20 | vs Jackson St | W60-45 | 2-4 | .333 | - | | James H. Hilton Coliseum · Ames, IA |
| 9 | Sat Jan 2 | vs #2Baylor | L65-76 | 2-5 | .286 | - | | James H. Hilton Coliseum · Ames, IA |
| 10 | Tue Jan 5 | at #4Texas | L72-78 | 2-6 | .250 | - | LHN | Moody Center · Austin, TX |
| 11 | Sat Jan 9 | vs #18Texas Tech | L64-91 | 2-7 | .222 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 12 | Wed Jan 13 | atKansas St | PPD | 2-22 | .083 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 13 | Sat Jan 16 | at #6Kansas | PPD | 2-22 | .083 | - | | Allen Fieldhouse · Lawrence, KS |
| 14 | Wed Jan 20 | vs#5Texas | PPD | 2-22 | .083 | - | | James H. Hilton Coliseum · Ames, IA |
| 15 | Sat Jan 23 | at#12Texas Tech | PPD | 2-22 | .083 | - | | United Supermarkets Arena · Lubbock, TX |
| 16 | Mon Jan 25 | vs Oklahoma St | L60-81 | 2-8 | .200 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 17 | Sat Jan 30 | at Mississippi St | L56-95 | 2-9 | .182 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 18 | Tue Feb 2 | vs#17West Virginia | L72-76 | 2-10 | .167 | - | | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Feb 6 | at #9Oklahoma | L72-79 | 2-11 | .154 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 20 | Tue Feb 9 | at TCU | L76-79 | 2-12 | .143 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 21 | Thu Feb 11 | atKansas | L64-97 | 2-13 | .133 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Sat Feb 13 | vsKansas | L50-64 | 2-14 | .125 | - | | James H. Hilton Coliseum · Ames, IA |
| 23 | Tue Feb 16 | atOklahoma St | L58-76 | 2-15 | .118 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Sat Feb 20 | vs#9Oklahoma | L56-66 | 2-16 | .111 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 25 | Tue Feb 23 | at#2Baylor | L72-77 | 2-17 | .105 | - | | Ferrell Center · Waco, TX |
| 26 | Sat Feb 27 | vsTCU | L72-76 | 2-18 | .100 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 27 | Tue Mar 2 | vs#15Texas | L67-81 | 2-19 | .095 | - | | James H. Hilton Coliseum · Ames, IA |
| 28 | Thu Mar 4 | at#18Texas Tech | L54-81 | 2-20 | .091 | - | | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Mar 6 | atKansas St | L56-61 | 2-21 | .087 | - | | Bramlage Coliseum · Manhattan, KS |
| 30 | Wed Mar 10 | atOklahoma | L73-79 | 2-22 | .083 | - | ESPN | Lloyd Noble Center · Norman, OK |
DePaul
Chicago St