| 1 | Tue Nov 5 | vs Miss Valley St | W110-74 | 1-0 | 1.000 | - | | James H. Hilton Coliseum · Ames, IA |
| 2 | Sat Nov 9 | at Oregon St | L74-80 | 1-1 | .500 | - | | Gill Coliseum · Corvallis, OR |
| 3 | Tue Nov 12 | vs N Illinois | W70-52 | 2-1 | .667 | - | | James H. Hilton Coliseum · Ames, IA |
| 4 | Tue Nov 19 | vs Southern Miss | W73-45 | 3-1 | .750 | - | | James H. Hilton Coliseum · Ames, IA |
| 5 | Wed Nov 27 | at Michigan | L76-83 | 3-2 | .600 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 6 | Thu Nov 28 | vs Alabama | W104-89 | 4-2 | .667 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 7 | Fri Nov 29 | vs Seton Hall | L76-84 | 4-3 | .571 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 8 | Wed Dec 4 | vs Kansas City | W79-61 | 5-3 | .625 | - | | James H. Hilton Coliseum · Ames, IA |
| 9 | Sun Dec 8 | vs#16Seton Hall | W76-66 | 6-3 | .667 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 10 | Thu Dec 12 | vs Iowa | L68-84 | 6-4 | .600 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 11 | Sun Dec 22 | vs Purdue FW | W89-59 | 7-4 | .636 | - | | James H. Hilton Coliseum · Ames, IA |
| 12 | Tue Dec 31 | vs FAMU | L68-70 | 7-5 | .583 | - | | James H. Hilton Coliseum · Ames, IA |
| 13 | Sat Jan 4 | at TCU | L79-81 (OT) | 7-6 | .538 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 14 | Wed Jan 8 | vs #3Kansas | L53-79 | 7-7 | .500 | - | | James H. Hilton Coliseum · Ames, IA |
| 15 | Sat Jan 11 | vs Oklahoma | W81-68 | 8-7 | .533 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 16 | Wed Jan 15 | at #2Baylor | L55-68 | 8-8 | .500 | - | | Ferrell Center · Waco, TX |
| 17 | Sat Jan 18 | at #23Texas Tech | L52-72 | 8-9 | .471 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 18 | Tue Jan 21 | vs Oklahoma St | W89-82 | 9-9 | .500 | - | | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Jan 25 | at Auburn | L76-80 | 9-10 | .474 | - | ESPNU | Neville Arena · Auburn, AL |
| 20 | Wed Jan 29 | vs#1Baylor | L53-67 | 9-11 | .450 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 21 | Sat Feb 1 | at Texas | L68-72 | 9-12 | .429 | - | LHN | Moody Center · Austin, TX |
| 22 | Wed Feb 5 | at #13West Virginia | L61-76 | 9-13 | .409 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 23 | Sat Feb 8 | vs Kansas St | W73-63 | 10-13 | .435 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 24 | Wed Feb 12 | atOklahoma | L61-90 | 10-14 | .417 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 25 | Sat Feb 15 | vsTexas | W81-52 | 11-14 | .440 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 26 | Mon Feb 17 | at#3Kansas | L71-91 | 11-15 | .423 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 27 | Sat Feb 22 | vsTexas Tech | L57-87 | 11-16 | .407 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 28 | Tue Feb 25 | vsTCU | W65-59 | 12-16 | .429 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 29 | Sat Feb 29 | atOklahoma St | L61-73 | 12-17 | .414 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 30 | Tue Mar 3 | vsWest Virginia | L71-77 | 12-18 | .400 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 31 | Sat Mar 7 | atKansas St | L63-79 | 12-19 | .387 | - | | Bramlage Coliseum · Manhattan, KS |
| 32 | Wed Mar 11 | atOklahoma St | L71-72 | 12-20 | .375 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
