| 1 | Mon Nov 6 | vs Green Bay | W85-44 | 1-0 | 1.000 | - | | James H. Hilton Coliseum · Ames, IA |
| 2 | Thu Nov 9 | vs Lindenwood | W102-47 | 2-0 | 1.000 | - | | James H. Hilton Coliseum · Ames, IA |
| 3 | Sun Nov 12 | vs Idaho St | W86-55 | 3-0 | 1.000 | - | | James H. Hilton Coliseum · Ames, IA |
| 4 | Sun Nov 19 | vs Grambling | W92-37 | 4-0 | 1.000 | - | | James H. Hilton Coliseum · Ames, IA |
| 5 | Thu Nov 23 | at VCU | W68-64 | 5-0 | 1.000 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 6 | Fri Nov 24 | at Virginia Tech | L62-71 | 5-1 | .833 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 7 | Sun Nov 26 | vs #12Texas A&M | L69-73 | 5-2 | .714 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 8 | Fri Dec 1 | at DePaul | W99-80 | 6-2 | .750 | - | FS1 | Wintrust Arena · Chicago, IL |
| 9 | Thu Dec 7 | vs Iowa | W90-65 | 7-2 | .778 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 10 | Sun Dec 10 | vs Prairie View | W107-56 | 8-2 | .800 | - | | James H. Hilton Coliseum · Ames, IA |
| 11 | Sun Dec 17 | vs FAMU | W96-58 | 9-2 | .818 | - | | James H. Hilton Coliseum · Ames, IA |
| 12 | Thu Dec 21 | vs E Illinois | W80-48 | 10-2 | .833 | - | | James H. Hilton Coliseum · Ames, IA |
| 13 | Sun Dec 31 | vs New Hampshire | W85-70 | 11-2 | .846 | - | | James H. Hilton Coliseum · Ames, IA |
| 14 | Sat Jan 6 | at #11Oklahoma | L63-71 | 11-3 | .786 | - | | Lloyd Noble Center · Norman, OK |
| 15 | Tue Jan 9 | vs #2Houston | W57-53 | 12-3 | .800 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 16 | Sat Jan 13 | vs Oklahoma St | W66-42 | 13-3 | .813 | - | | James H. Hilton Coliseum · Ames, IA |
| 17 | Tue Jan 16 | at #20BYU | L72-87 | 13-4 | .765 | #24 | | Marriott Center · Provo, UT |
| 18 | Sat Jan 20 | at #19TCU | W73-72 | 14-4 | .778 | #24 | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 19 | Wed Jan 24 | vs Kansas St | W78-67 | 15-4 | .789 | #23 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 20 | Sat Jan 27 | vs #7Kansas | W79-75 | 16-4 | .800 | #23 | CBS | James H. Hilton Coliseum · Ames, IA |
| 21 | Sat Feb 3 | at #18Baylor | L68-70 | 16-5 | .762 | #12 | ESPN2 | Ferrell Center · Waco, TX |
| 22 | Tue Feb 6 | at Texas | W70-65 | 17-5 | .773 | #14 | LHN | Moody Center · Austin, TX |
| 23 | Sat Feb 10 | vsTCU | W71-59 | 18-5 | .783 | #14 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 24 | Tue Feb 13 | at Cincinnati | W68-59 | 19-5 | .792 | #10 | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 25 | Sat Feb 17 | vs Texas Tech | W82-74 | 20-5 | .800 | #10 | | James H. Hilton Coliseum · Ames, IA |
| 26 | Mon Feb 19 | at#2Houston | L65-73 | 20-6 | .769 | #6 | ESPN | Fertitta Center · Houston, TX |
| 27 | Sat Feb 24 | vs West Virginia | W71-64 | 21-6 | .778 | #6 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 28 | Wed Feb 28 | vsOklahoma | W58-45 | 22-6 | .786 | #8 | | James H. Hilton Coliseum · Ames, IA |
| 29 | Sat Mar 2 | at UCF | W60-52 | 23-6 | .793 | #8 | | Addition Financial Arena · Orlando, FL |
| 30 | Wed Mar 6 | vs#20BYU | W68-63 | 24-6 | .800 | #6 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 31 | Sat Mar 9 | atKansas St | L58-65 | 24-7 | .774 | #6 | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 32 | Thu Mar 14 | vsKansas St | W76-57 | 25-7 | .781 | #7 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 33 | Fri Mar 15 | vs#14Baylor | W76-62 | 26-7 | .788 | #7 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 34 | Sat Mar 16 | at#1Houston | W69-41 | 27-7 | .794 | #7 | ESPN | Fertitta Center · Houston, TX |
| 35 | Thu Mar 21 | vs #15S Dakota St | W82-65 | 28-7 | .800 | #2 | truTV | James H. Hilton Coliseum · Ames, IA |
| 36 | Sat Mar 23 | vs #7Washington St | W67-56 | 29-7 | .806 | #2 | TNT | James H. Hilton Coliseum · Ames, IA |
| 37 | Thu Mar 28 | vs #3Illinois | L69-72 | 29-8 | .784 | #2 | TBS | James H. Hilton Coliseum · Ames, IA |
