| 1 | Mon Nov 3 | vs Fairleigh | 8:00 PM | 13-20 | .394 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 2 | Thu Nov 6 | vsGrambling | 8:00 PM | 12-22 | .353 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 3 | Mon Nov 10 | vsMississippi St | 8:00 PM | 21-13 | .618 | #16 | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 4 | Mon Nov 17 | vsStonehill | 8:00 PM | 15-17 | .469 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 5 | Mon Nov 24 | vs#5St John's | 4:30 PM | 31-5 | .861 | #16 | truTV | James H. Hilton Coliseum · Ames, IA |
| 6 | Tue Nov 25 | at#23Creighton | 2:30 PM | 25-11 | .694 | #16 | truTV | CHI Health Center Omaha · Omaha, NE |
| 7 | Wed Dec 3 | vsAlcorn St | 8:00 PM | 11-21 | .344 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 8 | Sat Dec 6 | at#1Purdue | 12:00 PM | 24-12 | .667 | #16 | CBS | Mackey Arena · West Lafayette, IN |
| 9 | Thu Dec 11 | vsIowa | 8:00 PM | 17-16 | .515 | #16 | FS1 | James H. Hilton Coliseum · Ames, IA |
| 10 | Sun Dec 14 | vsE Illinois | 1:00 PM | 12-19 | .387 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 11 | Sun Dec 21 | vsLong Beach St | 6:00 PM | 7-25 | .219 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 12 | Mon Dec 29 | vsHou Christian | 8:00 PM | 12-20 | .375 | #16 | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 13 | Fri Jan 2 | vsWest Virginia | 9:00 PM | 19-13 | .594 | #16 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 14 | Wed Jan 7 | atBaylor | 8:00 PM | 20-15 | .571 | #16 | Peacock | Ferrell Center · Waco, TX |
| 15 | Sat Jan 10 | vsOklahoma St | 4:00 PM | 17-18 | .486 | #16 | | James H. Hilton Coliseum · Ames, IA |
| 16 | Tue Jan 13 | at#19Kansas | 9:00 PM | 21-13 | .618 | #16 | | Allen Fieldhouse · Lawrence, KS |
| 17 | Sat Jan 17 | atCincinnati | 2:00 PM | 19-16 | .543 | #16 | Peacock | Fifth Third Arena · Cincinnati, OH |
| 18 | Tue Jan 20 | vsUCF | 7:00 PM | 20-17 | .541 | #16 | CBS | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Jan 24 | atOklahoma St | 4:00 PM | 17-18 | .486 | #16 | Peacock | Gallagher-Iba Arena · Stillwater, OK |
| 20 | Thu Jan 29 | vsColorado | 7:00 PM | 14-21 | .400 | #16 | FS1 | James H. Hilton Coliseum · Ames, IA |
| 21 | Sun Feb 1 | atKansas St | 2:00 PM | 16-17 | .485 | #16 | FOX | Bramlage Coliseum · Manhattan, KS |
| 22 | Sat Feb 7 | vsBaylor | 2:00 PM | 20-15 | .571 | #16 | | James H. Hilton Coliseum · Ames, IA |
| 23 | Tue Feb 10 | atTCU | 9:00 PM | 16-16 | .500 | #16 | FS1 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 24 | Sat Feb 14 | vs#19Kansas | 1:00 PM | 21-13 | .618 | #16 | ABC | James H. Hilton Coliseum · Ames, IA |
| 25 | Mon Feb 16 | vs#2Houston | 9:00 PM | 35-5 | .875 | #16 | ESPN | James H. Hilton Coliseum · Ames, IA |
| 26 | Sat Feb 21 | at#8BYU | 10:30 PM | 26-10 | .722 | #16 | ESPN | Marriott Center · Provo, UT |
| 27 | Tue Feb 24 | atUtah | 9:00 PM | 16-17 | .485 | #16 | FS1 | Jon M. Huntsman Center · Salt Lake City, UT |
| 28 | Sat Feb 28 | vs#10Texas Tech | 4:00 PM | 28-9 | .757 | #16 | CBS | James H. Hilton Coliseum · Ames, IA |
| 29 | Mon Mar 2 | at#13Arizona | 9:00 PM | 24-13 | .649 | #16 | ESPN | McKale Center · Tucson, AZ |
| 30 | Sat Mar 7 | vsArizona St | 2:00 PM | 13-20 | .394 | #16 | FS1 | James H. Hilton Coliseum · Ames, IA |
