| 1 | Tue Nov 9 | vs Quinnipiac | W83-69 | 1-0 | 1.000 | #21 | | XFINITY Center · College Park, MD |
| 2 | Thu Nov 11 | vsG Washington | W71-64 | 2-0 | 1.000 | #21 | BTN | XFINITY Center · College Park, MD |
| 3 | Sat Nov 13 | vsVermont | W68-57 | 3-0 | 1.000 | - | | XFINITY Center · College Park, MD |
| 4 | Wed Nov 17 | vsGeorge Mason | L66-71 | 3-1 | .750 | #20 | BTN | XFINITY Center · College Park, MD |
| 5 | Fri Nov 19 | vsHofstra | W69-67 | 4-1 | .800 | #20 | FS1 | XFINITY Center · College Park, MD |
| 6 | Thu Nov 25 | vsRichmond | W86-80 | 5-1 | .833 | - | CBSSN | XFINITY Center · College Park, MD |
| 7 | Sat Nov 27 | vsLouisville | L55-63 | 5-2 | .714 | - | CBSSN | XFINITY Center · College Park, MD |
| 8 | Wed Dec 1 | vsVirginia Tech | L58-62 | 5-3 | .625 | - | ESPN2 | XFINITY Center · College Park, MD |
| 9 | Sun Dec 5 | vsNorthwestern | L61-67 | 5-4 | .556 | - | BTN | XFINITY Center · College Park, MD |
| 10 | Sun Dec 12 | vsFlorida | W70-68 | 6-4 | .600 | - | BTN | XFINITY Center · College Park, MD |
| 11 | Tue Dec 28 | vsLehigh | W76-55 | 7-4 | .636 | - | BTN | XFINITY Center · College Park, MD |
| 12 | Thu Dec 30 | vsBrown | W81-67 | 8-4 | .667 | - | BTN | XFINITY Center · College Park, MD |
| 13 | Mon Jan 3 | atIowa | L75-80 | 8-5 | .615 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Thu Jan 6 | atIllinois | L64-76 | 8-6 | .571 | - | ESPN2 | State Farm Center · Champaign, IL |
| 15 | Sun Jan 9 | vs23Wisconsin | L69-70 | 8-7 | .533 | - | BTN | XFINITY Center · College Park, MD |
| 16 | Wed Jan 12 | atNorthwestern | W94-87 (2OT) | 9-7 | .563 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 17 | Sat Jan 15 | vsRutgers | L59-70 | 9-8 | .529 | - | BTN | XFINITY Center · College Park, MD |
| 18 | Tue Jan 18 | atMichigan | L64-83 | 9-9 | .500 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 19 | Fri Jan 21 | vs17Illinois | W81-65 | 10-9 | .526 | - | FS1 | XFINITY Center · College Park, MD |
| 20 | Tue Jan 25 | atRutgers | W68-60 | 11-9 | .550 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 21 | Sat Jan 29 | vsIndiana | L55-68 | 11-10 | .524 | - | FOX | XFINITY Center · College Park, MD |
| 22 | Tue Feb 1 | vs13Michigan St | L63-65 | 11-11 | .500 | - | ESPN2 | XFINITY Center · College Park, MD |
| 23 | Sun Feb 6 | at16Ohio State | L67-82 | 11-12 | .478 | - | CBS | Value City Arena · Columbus, OH |
| 24 | Thu Feb 10 | vsIowa | L87-110 | 11-13 | .458 | - | ESPN2 | XFINITY Center · College Park, MD |
| 25 | Sun Feb 13 | at3Purdue | L61-62 | 11-14 | .440 | - | CBS | Mackey Arena · West Lafayette, IN |
| 26 | Fri Feb 18 | atNebraska | W90-74 | 12-14 | .462 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 27 | Mon Feb 21 | vsPenn State | W67-61 | 13-14 | .481 | - | ESPN2 | XFINITY Center · College Park, MD |
| 28 | Thu Feb 24 | atIndiana | L64-74 | 13-15 | .464 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sun Feb 27 | vs22Ohio State | W75-60 | 14-15 | .483 | - | CBS | XFINITY Center · College Park, MD |
| 30 | Wed Mar 2 | vsMinnesota | W84-73 | 15-15 | .500 | - | BTN | XFINITY Center · College Park, MD |
| 31 | Sun Mar 6 | atMichigan St | L67-77 | 15-16 | .484 | - | CBS | Breslin Center · East Lansing, MI |
| 32 | Thu Mar 10 | atMichigan St | L72-76 | 15-17 | .469 | - | BTN | Breslin Center · East Lansing, MI |
