| 1 | Mon Nov 7 | vs Niagara | W71-49 | 1-0 | 1.000 | - | | XFINITY Center · College Park, MD |
| 2 | Thu Nov 10 | vs W Carolina | W71-51 | 2-0 | 1.000 | - | | XFINITY Center · College Park, MD |
| 3 | Tue Nov 15 | vs Binghamton | W76-52 | 3-0 | 1.000 | - | BTN | XFINITY Center · College Park, MD |
| 4 | Sat Nov 19 | vs Saint Louis | W95-67 | 4-0 | 1.000 | - | ESPNEWS | XFINITY Center · College Park, MD |
| 5 | Sun Nov 20 | vs Miami | W88-70 | 5-0 | 1.000 | - | ESPN | XFINITY Center · College Park, MD |
| 6 | Fri Nov 25 | vs Coppin St | W95-79 | 6-0 | 1.000 | #23 | | XFINITY Center · College Park, MD |
| 7 | Tue Nov 29 | at Louisville | W79-54 | 7-0 | 1.000 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 8 | Fri Dec 2 | vs #16Illinois | W71-66 | 8-0 | 1.000 | #22 | BTN | XFINITY Center · College Park, MD |
| 9 | Tue Dec 6 | at Wisconsin | L59-64 | 8-1 | .889 | #13 | ESPN2 | Kohl Center · Madison, WI |
| 10 | Sun Dec 11 | vs Tennessee | L53-56 | 8-2 | .800 | - | FS1 | XFINITY Center · College Park, MD |
| 11 | Wed Dec 14 | vs #16UCLA | L60-87 | 8-3 | .727 | #20 | FS1 | XFINITY Center · College Park, MD |
| 12 | Thu Dec 22 | vs Saint Peter's | W75-45 | 9-3 | .750 | - | BTN | XFINITY Center · College Park, MD |
| 13 | Thu Dec 29 | vs UMBC | W80-64 | 10-3 | .769 | - | ESPNU | XFINITY Center · College Park, MD |
| 14 | Sun Jan 1 | at Michigan | L46-81 | 10-4 | .714 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 15 | Thu Jan 5 | at Rutgers | L50-64 | 10-5 | .667 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 16 | Sun Jan 8 | vs #24Ohio State | W80-73 | 11-5 | .688 | - | ESPN | XFINITY Center · College Park, MD |
| 17 | Sun Jan 15 | at Iowa | L67-81 | 11-6 | .647 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 18 | Thu Jan 19 | vsMichigan | W64-58 | 12-6 | .667 | - | ESPN | XFINITY Center · College Park, MD |
| 19 | Sun Jan 22 | at #3Purdue | L55-58 | 12-7 | .632 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 20 | Wed Jan 25 | vsWisconsin | W73-55 | 13-7 | .650 | - | BTN | XFINITY Center · College Park, MD |
| 21 | Sat Jan 28 | vs Nebraska | W82-63 | 14-7 | .667 | - | BTN | XFINITY Center · College Park, MD |
| 22 | Tue Jan 31 | vs #21Indiana | W66-55 | 15-7 | .682 | - | ESPN2 | XFINITY Center · College Park, MD |
| 23 | Sat Feb 4 | at Minnesota | W81-46 | 16-7 | .696 | - | BTN | Williams Arena · Minneapolis, MN |
| 24 | Tue Feb 7 | at Michigan St | L58-63 | 16-8 | .667 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 25 | Sat Feb 11 | vs Penn State | W74-68 | 17-8 | .680 | - | BTN | XFINITY Center · College Park, MD |
| 26 | Thu Feb 16 | vs#3Purdue | W68-54 | 18-8 | .692 | - | BTN | XFINITY Center · College Park, MD |
| 27 | Sun Feb 19 | atNebraska | L66-70 (OT) | 18-9 | .667 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 28 | Wed Feb 22 | vsMinnesota | W88-70 | 19-9 | .679 | - | BTN | XFINITY Center · College Park, MD |
| 29 | Sun Feb 26 | vs #21Northwestern | W75-59 | 20-9 | .690 | - | BTN | XFINITY Center · College Park, MD |
| 30 | Wed Mar 1 | atOhio State | L62-73 | 20-10 | .667 | #21 | BTN | Value City Arena · Columbus, OH |
| 31 | Sun Mar 5 | atPenn State | L64-65 | 20-11 | .645 | #21 | BTN | Bryce Jordan Center · University Park, PA |
| 32 | Thu Mar 9 | vsMinnesota | W70-54 | 21-11 | .656 | - | BTN | XFINITY Center · College Park, MD |
| 33 | Fri Mar 10 | atIndiana | L60-70 | 21-12 | .636 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 34 | Thu Mar 16 | vs #9West Virginia | W67-65 | 22-12 | .647 | #8 | CBS | XFINITY Center · College Park, MD |
| 35 | Sat Mar 18 | at #1Alabama | L51-73 | 22-13 | .629 | #8 | TBS | Coleman Coliseum · Tuscaloosa, AL |
