| 1 | Tue Nov 5 | vs Holy Cross | W95-71 | 1-0 | 1.000 | #7 | | XFINITY Center · College Park, MD |
| 2 | Sat Nov 9 | vsRhode Island | W73-55 | 2-0 | 1.000 | #7 | FS1 | XFINITY Center · College Park, MD |
| 3 | Sat Nov 16 | vsOakland | W80-50 | 3-0 | 1.000 | #7 | | XFINITY Center · College Park, MD |
| 4 | Tue Nov 19 | vsFairfield | W74-55 | 4-0 | 1.000 | #6 | BTN | XFINITY Center · College Park, MD |
| 5 | Fri Nov 22 | vsGeorge Mason | W86-63 | 5-0 | 1.000 | #6 | BTN | XFINITY Center · College Park, MD |
| 6 | Thu Nov 28 | atTemple | W76-69 | 6-0 | 1.000 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 7 | Fri Nov 29 | atHarvard | W80-73 | 7-0 | 1.000 | - | ESPN2 | Lavietes Pavilion · Cambridge, MA |
| 8 | Sun Dec 1 | atMarquette | W84-63 | 8-0 | 1.000 | - | ESPN | Fiserv Forum · Milwaukee, WI |
| 9 | Wed Dec 4 | vsNotre Dame | W72-51 | 9-0 | 1.000 | - | ESPN | XFINITY Center · College Park, MD |
| 10 | Sat Dec 7 | vsIllinois | W59-58 | 10-0 | 1.000 | #3 | ESPN2 | XFINITY Center · College Park, MD |
| 11 | Tue Dec 10 | atPenn State | L69-76 | 10-1 | .909 | #4 | ESPN2 | Bryce Jordan Center · University Park, PA |
| 12 | Thu Dec 19 | atSeton Hall | L48-52 | 10-2 | .833 | #7 | FS1 | Prudential Center · Newark, NJ |
| 13 | Sun Dec 29 | vsBryant | W84-70 | 11-2 | .846 | #13 | BTN | XFINITY Center · College Park, MD |
| 14 | Sat Jan 4 | vsIndiana | W75-59 | 12-2 | .857 | #15 | FOX | XFINITY Center · College Park, MD |
| 15 | Tue Jan 7 | vs11Ohio State | W67-55 | 13-2 | .867 | #12 | ESPN | XFINITY Center · College Park, MD |
| 16 | Fri Jan 10 | atIowa | L49-67 | 13-3 | .813 | #12 | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Tue Jan 14 | atWisconsin | L54-56 | 13-4 | .765 | #17 | ESPN2 | Kohl Center · Madison, WI |
| 18 | Sat Jan 18 | vsPurdue | W57-50 | 14-4 | .778 | #17 | ESPN2 | XFINITY Center · College Park, MD |
| 19 | Tue Jan 21 | atNorthwestern | W77-66 | 15-4 | .789 | #17 | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 20 | Sun Jan 26 | atIndiana | W77-76 | 16-4 | .800 | #17 | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 21 | Thu Jan 30 | vs18Iowa | W82-72 | 17-4 | .810 | #15 | BTN | XFINITY Center · College Park, MD |
| 22 | Tue Feb 4 | vsRutgers | W56-51 | 18-4 | .818 | #9 | FS1 | XFINITY Center · College Park, MD |
| 23 | Fri Feb 7 | at20Illinois | W75-66 | 19-4 | .826 | #9 | FS1 | State Farm Center · Champaign, IL |
| 24 | Tue Feb 11 | vsNebraska | W72-70 | 20-4 | .833 | #9 | BTN | XFINITY Center · College Park, MD |
| 25 | Sat Feb 15 | atMichigan St | W67-60 | 21-4 | .840 | #9 | ESPN | Breslin Center · East Lansing, MI |
| 26 | Tue Feb 18 | vsNorthwestern | W76-67 | 22-4 | .846 | - | BTN | XFINITY Center · College Park, MD |
| 27 | Sun Feb 23 | at25Ohio State | L72-79 | 22-5 | .815 | #7 | CBS | Value City Arena · Columbus, OH |
| 28 | Wed Feb 26 | atMinnesota | W74-73 | 23-5 | .821 | #9 | BTN | Williams Arena · Minneapolis, MN |
| 29 | Sat Feb 29 | vs24Michigan St | L66-78 | 23-6 | .793 | #9 | ESPN | XFINITY Center · College Park, MD |
| 30 | Tue Mar 3 | atRutgers | L67-78 | 23-7 | .767 | #9 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 31 | Sun Mar 8 | vs25Michigan | W83-70 | 24-7 | .774 | #9 | FOX | XFINITY Center · College Park, MD |
