| 1 | Mon Nov 3 | vs Coppin St | W83-61 | 1-0 | 1.000 | - | BTN | XFINITY Center · College Park, MD |
| 2 | Fri Nov 7 | vsGeorgetown | L60-70 | 1-1 | .500 | - | FS1 | XFINITY Center · College Park, MD |
| 3 | Tue Nov 11 | vsAlcorn St | W84-64 | 2-1 | .667 | - | B1G+ | XFINITY Center · College Park, MD |
| 4 | Sat Nov 15 | atMarquette | W89-82 | 3-1 | .750 | - | Peacock | Fiserv Forum · Milwaukee, WI |
| 5 | Wed Nov 19 | vsMount St Mary | W95-90 (OT) | 4-1 | .800 | - | B1G+ | XFINITY Center · College Park, MD |
| 6 | Mon Nov 24 | vsUNLV | W74-67 | 5-1 | .833 | - | TNT | XFINITY Center · College Park, MD |
| 7 | Tue Nov 25 | at12Gonzaga | L61-100 | 5-2 | .714 | - | truTV | McCarthey Athletic Center · Spokane, WA |
| 8 | Wed Nov 26 | at8Alabama | L72-105 | 5-3 | .625 | - | TNT | Coleman Coliseum · Tuscaloosa, AL |
| 9 | Tue Dec 2 | vsWagner | W89-63 | 6-3 | .667 | - | BTN | XFINITY Center · College Park, MD |
| 10 | Sat Dec 6 | atIowa | L64-83 | 6-4 | .600 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Sat Dec 13 | vs2Michigan | L83-101 | 6-5 | .545 | - | FOX | XFINITY Center · College Park, MD |
| 12 | Sat Dec 20 | at23Virginia | L72-80 | 6-6 | .500 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 13 | Sun Dec 28 | vsOld Dominion | W73-58 | 7-6 | .538 | - | BTN | XFINITY Center · College Park, MD |
| 14 | Fri Jan 2 | vsOregon | L54-64 | 7-7 | .500 | - | Peacock | XFINITY Center · College Park, MD |
| 15 | Wed Jan 7 | vsIndiana | L66-84 | 7-8 | .467 | - | BTN | XFINITY Center · College Park, MD |
| 16 | Sat Jan 10 | atUCLA | L55-67 | 7-9 | .438 | - | FOX | Pauley Pavilion · Los Angeles, CA |
| 17 | Tue Jan 13 | atUSC | L71-88 | 7-10 | .412 | - | FS1 | Galen Center · Los Angeles, CA |
| 18 | Sun Jan 18 | vsPenn State | W96-73 | 8-10 | .444 | - | BTN | XFINITY Center · College Park, MD |
| 19 | Wed Jan 21 | at11Illinois | L70-89 | 8-11 | .421 | - | BTN | State Farm Center · Champaign, IL |
| 20 | Sat Jan 24 | at10Michigan St | L48-91 | 8-12 | .400 | - | CBS | Breslin Center · East Lansing, MI |
| 21 | Sun Feb 1 | vs12Purdue | L63-93 | 8-13 | .381 | - | CBS | XFINITY Center · College Park, MD |
| 22 | Thu Feb 5 | vsOhio State | L62-82 | 8-14 | .364 | - | FS1 | XFINITY Center · College Park, MD |
| 23 | Sun Feb 8 | atMinnesota | W67-62 | 9-14 | .391 | - | BTN | Williams Arena · Minneapolis, MN |
| 24 | Wed Feb 11 | vsIowa | W77-70 | 10-14 | .417 | - | FS1 | XFINITY Center · College Park, MD |
| 25 | Sun Feb 15 | atRutgers | L57-68 | 10-15 | .400 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 26 | Wed Feb 18 | atNorthwestern | L74-78 | 10-16 | .385 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 27 | Sat Feb 21 | vsWashington | W64-60 | 11-16 | .407 | - | Peacock | XFINITY Center · College Park, MD |
| 28 | Wed Feb 25 | at12Nebraska | L61-74 | 11-17 | .393 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 29 | Sun Mar 1 | vsRutgers | L65-69 | 11-18 | .379 | - | FS1 | XFINITY Center · College Park, MD |
| 30 | Wed Mar 4 | atWisconsin | L45-78 | 11-19 | .367 | - | FS1 | Kohl Center · Madison, WI |
| 31 | Sun Mar 8 | vs11Illinois | L72-78 | 11-20 | .355 | - | FOX | XFINITY Center · College Park, MD |
| 32 | Tue Mar 10 | atOregon | W70-60 | 12-20 | .375 | - | Peacock | Matthew Knight Arena · Eugene, OR |
| 33 | Wed Mar 11 | atIowa | L64-75 | 12-21 | .364 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
