| 1 | Wed Nov 25 | vs McNeese | W102-55 | 1-0 | 1.000 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 2 | Thu Nov 26 | vs Nevada | L66-69 | 1-1 | .500 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 3 | Sat Nov 28 | vs N Dakota St | W79-57 | 2-1 | .667 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 4 | Tue Dec 1 | vs South Dakota | W76-69 | 3-1 | .750 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 6 | Wed Dec 9 | vs Georgia Tech | L64-75 | 3-2 | .600 | - | ESPN2 | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Fri Dec 11 | at #8Creighton | L74-98 | 3-3 | .500 | - | BTN | CHI Health Center Omaha · Omaha, NE |
| 8 | Thu Dec 17 | vs TBD | W110-64 | 4-3 | .571 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 9 | Tue Dec 22 | at #9Wisconsin | L53-67 | 4-4 | .500 | - | FS1 | Kohl Center · Madison, WI |
| 10 | Fri Dec 25 | vs #19Michigan | L69-80 | 4-5 | .444 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 11 | Wed Dec 30 | at #25Ohio State | L54-90 | 4-6 | .400 | - | BTN | Value City Arena · Columbus, OH |
| 12 | Sat Jan 2 | vs #17Michigan St | L77-84 | 4-7 | .364 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 14 | Sun Jan 10 | vs Indiana | L76-84 | 4-8 | .333 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Wed Jan 13 | vs #14Illinois | PPD | 7-20 | .259 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 16 | Sat Jan 16 | at Maryland | PPD | 7-20 | .259 | - | BTN | XFINITY Center · College Park, MD |
| 17 | Wed Jan 20 | vs #17Minnesota | PPD | 7-20 | .259 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 18 | Sun Jan 24 | at #4Iowa | PPD | 7-20 | .259 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 19 | Sat Feb 6 | atMichigan St | L56-66 | 4-9 | .308 | - | BTN | Breslin Center · East Lansing, MI |
| 20 | Mon Feb 8 | atMinnesota | L61-79 | 4-10 | .286 | - | BTN | Williams Arena · Minneapolis, MN |
| 21 | Wed Feb 10 | vs#21Wisconsin | L48-61 | 4-11 | .267 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 22 | Fri Feb 12 | vs#6Illinois | L72-77 (OT) | 4-12 | .250 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 23 | Sun Feb 14 | at Penn State | W62-61 | 5-12 | .294 | - | BTN | Bryce Jordan Center · University Park, PA |
| 24 | Tue Feb 16 | atMaryland | L50-64 | 5-13 | .278 | - | BTN | XFINITY Center · College Park, MD |
| 25 | Wed Feb 17 | atMaryland | L71-79 | 5-14 | .263 | - | BTN | XFINITY Center · College Park, MD |
| 26 | Sat Feb 20 | vs Purdue | L58-75 | 5-15 | .250 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 27 | Tue Feb 23 | vsPenn State | L83-86 | 5-16 | .238 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 28 | Thu Feb 25 | at#5Illinois | L70-86 | 5-17 | .227 | - | BTN | State Farm Center · Champaign, IL |
| 29 | Sat Feb 27 | vsMinnesota | W78-74 | 6-17 | .261 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 30 | Mon Mar 1 | vs Rutgers | W72-51 | 7-17 | .292 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 31 | Thu Mar 4 | at#5Iowa | L64-102 | 7-18 | .280 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 32 | Sun Mar 7 | at Northwestern | L78-79 | 7-19 | .269 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 33 | Wed Mar 10 | atPenn State | L66-72 | 7-20 | .259 | - | BTN | Bryce Jordan Center · University Park, PA |
