| 1 | Mon Nov 4 | vs UT Rio Grande | W87-67 | 1-0 | 1.000 | - | B1G+ | Pinnacle Bank Arena · Lincoln, NE |
| 2 | Sat Nov 9 | vsBethune | W63-58 | 2-0 | 1.000 | - | B1G+ | Pinnacle Bank Arena · Lincoln, NE |
| 3 | Wed Nov 13 | vsFairleigh | W86-60 | 3-0 | 1.000 | - | B1G+ | Pinnacle Bank Arena · Lincoln, NE |
| 4 | Sun Nov 17 | atSaint Mary's | L74-77 | 3-1 | .750 | - | BTN | University Credit Union Pavilion · Moraga, CA |
| 5 | Fri Nov 22 | at14Creighton | W74-63 | 4-1 | .800 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 6 | Wed Nov 27 | vsSouth Dakota | W96-79 | 5-1 | .833 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Sun Dec 1 | vsNorth Florida | W103-72 | 6-1 | .857 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 8 | Sat Dec 7 | atMichigan St | L52-89 | 6-2 | .750 | - | BTN | Breslin Center · East Lansing, MI |
| 9 | Fri Dec 13 | vsIndiana | W85-68 | 7-2 | .778 | - | FOX | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Sun Dec 22 | atMurray St | W66-49 | 8-2 | .800 | - | ESPN | Stan Sheriff Center · Honolulu, HI |
| 11 | Mon Dec 23 | atHawai'i | W69-55 | 9-2 | .818 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 12 | Wed Dec 25 | vsOregon St | W78-66 | 10-2 | .833 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 13 | Mon Dec 30 | vsSouthern | W77-43 | 11-2 | .846 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 14 | Sat Jan 4 | vs15UCLA | W66-58 | 12-2 | .857 | - | FOX | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Tue Jan 7 | atIowa | L87-97 (OT) | 12-3 | .800 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 16 | Sun Jan 12 | at20Purdue | L68-104 | 12-4 | .750 | - | BTN | Mackey Arena · West Lafayette, IN |
| 17 | Thu Jan 16 | vsRutgers | L82-85 | 12-5 | .706 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 18 | Sun Jan 19 | atMaryland | L66-69 | 12-6 | .667 | - | BTN | XFINITY Center · College Park, MD |
| 19 | Wed Jan 22 | vsUSC | L73-78 | 12-7 | .632 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 20 | Sun Jan 26 | at18Wisconsin | L55-83 | 12-8 | .600 | - | BTN | Kohl Center · Madison, WI |
| 21 | Thu Jan 30 | vs18Illinois | W80-74 (OT) | 13-8 | .619 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 22 | Sun Feb 2 | at16Oregon | W77-71 | 14-8 | .636 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 23 | Wed Feb 5 | atWashington | W86-72 | 15-8 | .652 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 24 | Sun Feb 9 | vsOhio State | W79-71 | 16-8 | .667 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 25 | Thu Feb 13 | vs25Maryland | L75-83 | 16-9 | .640 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 26 | Sun Feb 16 | atNorthwestern | W68-64 | 17-9 | .654 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 27 | Wed Feb 19 | atPenn State | L72-89 | 17-10 | .630 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Mon Feb 24 | vs15Michigan | L46-49 | 17-11 | .607 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 29 | Sat Mar 1 | vsMinnesota | L65-67 | 17-12 | .586 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 30 | Tue Mar 4 | atOhio State | L114-116 (2OT) | 17-13 | .567 | - | Peacock | Value City Arena · Columbus, OH |
| 31 | Sun Mar 9 | vsIowa | L68-83 | 17-14 | .548 | - | FOX | Pinnacle Bank Arena · Lincoln, NE |
| 32 | Mon Mar 31 | atArizona St | W86-78 | 18-14 | .563 | - | FS1 | Desert Financial Arena · Tempe, AZ |
| 33 | Wed Apr 2 | atGeorgetown | W81-69 | 19-14 | .576 | - | FS1 | Capital One Arena · Washington, D.C. |
| 34 | Sat Apr 5 | vsBoise St | W79-69 | 20-14 | .588 | - | FOX | T-Mobile Arena · Las Vegas, NV |
| 35 | Sun Apr 6 | atUCF | W77-66 | 21-14 | .600 | - | FOX | T-Mobile Arena · Las Vegas, NV |
