| 1 | Tue Nov 9 | vs W Illinois | L74-75 | 0-1 | .000 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 2 | Fri Nov 12 | vsSam Houston | W74-65 | 1-1 | .500 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 3 | Tue Nov 16 | vsCreighton | L69-77 | 1-2 | .333 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 4 | Fri Nov 19 | vsIdaho St | W78-60 | 2-2 | .500 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 5 | Sun Nov 21 | vsSouthern | W82-59 | 3-2 | .600 | - | ESPNU | Pinnacle Bank Arena · Lincoln, NE |
| 6 | Tue Nov 23 | vsTennessee St | W79-73 | 4-2 | .667 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Sat Nov 27 | vsSouth Dakota | W83-70 | 5-2 | .714 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 8 | Wed Dec 1 | atNC State | L100-104 (4OT) | 5-3 | .625 | - | ESPNU | PNC Arena · Raleigh, NC |
| 9 | Sat Dec 4 | atIndiana | L55-68 | 5-4 | .556 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 10 | Tue Dec 7 | vsMichigan | L67-102 | 5-5 | .500 | - | ESPN2 | Pinnacle Bank Arena · Lincoln, NE |
| 11 | Sat Dec 11 | atAuburn | L68-99 | 5-6 | .455 | - | ESPN2 | State Farm Arena · Atlanta, GA |
| 12 | Sun Dec 19 | vsKansas St | L58-67 | 5-7 | .417 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 13 | Wed Dec 22 | vsKennesaw St | W88-74 | 6-7 | .462 | - | ESPNU | Pinnacle Bank Arena · Lincoln, NE |
| 14 | Sun Jan 2 | vs13Ohio State | L79-87 (OT) | 6-8 | .429 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Wed Jan 5 | at10Michigan St | L67-79 | 6-9 | .400 | - | BTN | Breslin Center · East Lansing, MI |
| 16 | Sat Jan 8 | atRutgers | L65-93 | 6-10 | .375 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Tue Jan 11 | vs25Illinois | L71-81 | 6-11 | .353 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 18 | Fri Jan 14 | at7Purdue | L65-92 | 6-12 | .333 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 19 | Mon Jan 17 | vsIndiana | L71-78 | 6-13 | .316 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 20 | Sat Jan 22 | at19Ohio State | PPD | 10-22 | .313 | - | | Value City Arena · Columbus, OH |
| 21 | Thu Jan 27 | vs11Wisconsin | L65-73 | 6-14 | .300 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 22 | Sat Jan 29 | vsRutgers | L61-63 | 6-15 | .286 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 23 | Tue Feb 1 | atMichigan | L79-85 | 6-16 | .273 | - | BTN | Crisler Center · Ann Arbor, MI |
| 24 | Sat Feb 5 | vsNorthwestern | L63-87 | 6-17 | .261 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 25 | Wed Feb 9 | vsMinnesota | W78-65 | 7-17 | .292 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 26 | Sun Feb 13 | atIowa | L75-98 | 7-18 | .280 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 27 | Fri Feb 18 | vsMaryland | L74-90 | 7-19 | .269 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 28 | Tue Feb 22 | atNorthwestern | L65-77 | 7-20 | .259 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 29 | Fri Feb 25 | vs25Iowa | L78-88 | 7-21 | .250 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 30 | Sun Feb 27 | atPenn State | W93-70 | 8-21 | .276 | - | BTN | Bryce Jordan Center · University Park, PA |
| 31 | Tue Mar 1 | at23Ohio State | W78-70 | 9-21 | .300 | - | BTN | Value City Arena · Columbus, OH |
| 32 | Sun Mar 6 | at10Wisconsin | W74-73 | 10-21 | .323 | - | BTN | Kohl Center · Madison, WI |
| 33 | Wed Mar 9 | atNorthwestern | L69-71 | 10-22 | .313 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
