| 1 | Tue Nov 5 | vs TBD | W94-66 | 1-0 | 1.000 | - | | Athletics Center O'rena · Rochester, MI |
| 2 | Fri Nov 8 | atDelaware | L53-56 | 1-1 | .500 | - | | Bob Carpenter Center · Newark, DE |
| 3 | Sat Nov 9 | vsUTSA | W75-62 | 2-1 | .667 | - | | Athletics Center O'rena · Rochester, MI |
| 4 | Sun Nov 10 | vsS Illinois | W61-52 | 3-1 | .750 | - | | Athletics Center O'rena · Rochester, MI |
| 5 | Sat Nov 16 | at7Maryland | L50-80 | 3-2 | .600 | - | | XFINITY Center · College Park, MD |
| 6 | Mon Nov 18 | vsTBD | W60-50 | 4-2 | .667 | - | | Athletics Center O'rena · Rochester, MI |
| 7 | Mon Nov 25 | atN Illinois | L50-74 | 4-3 | .571 | - | | NIU Convocation Center · Dekalb, IL |
| 8 | Sat Nov 30 | atToledo | L63-65 | 4-4 | .500 | - | | Savage Arena · Toledo, OH |
| 9 | Tue Dec 3 | atW Michigan | W72-62 | 5-4 | .556 | - | | University Arena (MI) · Kalamazoo, MI |
| 10 | Sat Dec 7 | atBowling Green | L65-68 | 5-5 | .500 | - | | Stroh Center · Bowling Green, OH |
| 11 | Sat Dec 14 | vs16Michigan St | L49-72 | 5-6 | .455 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 12 | Wed Dec 18 | atSyracuse | L62-74 | 5-7 | .417 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 13 | Sat Dec 21 | vsFairfield | L59-61 (OT) | 5-8 | .385 | - | | Athletics Center O'rena · Rochester, MI |
| 14 | Sat Dec 28 | vsDetroit Mercy | W78-69 | 6-8 | .429 | - | | Athletics Center O'rena · Rochester, MI |
| 15 | Fri Jan 3 | vsWright St | L69-96 | 6-9 | .400 | - | ESPNU | Athletics Center O'rena · Rochester, MI |
| 16 | Sun Jan 5 | vsN Kentucky | L64-75 | 6-10 | .375 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Thu Jan 9 | atYoungstown St | L60-61 | 6-11 | .353 | - | | Beeghly Center · Youngstown, OH |
| 18 | Sat Jan 11 | atCleveland St | W68-55 | 7-11 | .389 | - | | Wolstein Center · Cleveland, OH |
| 19 | Thu Jan 16 | atGreen Bay | L69-73 | 7-12 | .368 | - | | Resch Center · Ashwaubenon, WI |
| 20 | Sat Jan 18 | atMilwaukee | L68-73 | 7-13 | .350 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Thu Jan 23 | vsUIC | L50-80 | 7-14 | .333 | - | | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 25 | vsIU Indy | L85-89 (OT) | 7-15 | .318 | - | | Athletics Center O'rena · Rochester, MI |
| 23 | Fri Jan 31 | atDetroit Mercy | W77-64 | 8-15 | .348 | - | | Calihan Hall · Detroit, MI |
| 24 | Thu Feb 6 | atN Kentucky | L70-73 | 8-16 | .333 | - | | Truist Arena · Highland Heights, KY |
| 25 | Sat Feb 8 | atWright St | L71-83 | 8-17 | .320 | - | | Nutter Center · Dayton, OH |
| 26 | Thu Feb 13 | vsCleveland St | W79-74 | 9-17 | .346 | - | | Athletics Center O'rena · Rochester, MI |
| 27 | Sat Feb 15 | vsYoungstown St | W72-64 | 10-17 | .370 | - | | Athletics Center O'rena · Rochester, MI |
| 28 | Fri Feb 21 | vsMilwaukee | W75-68 | 11-17 | .393 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Sun Feb 23 | vsGreen Bay | W92-88 (2OT) | 12-17 | .414 | - | | Athletics Center O'rena · Rochester, MI |
| 30 | Thu Feb 27 | atIU Indy | L68-71 | 12-18 | .400 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 29 | atUIC | W68-66 | 13-18 | .419 | - | | Credit Union 1 Arena · Chicago, IL |
| 32 | Tue Mar 3 | vsCleveland St | W80-59 | 14-18 | .438 | - | | Athletics Center O'rena · Rochester, MI |
| 33 | Thu Mar 5 | atGreen Bay | L63-78 | 14-19 | .424 | - | | Resch Center · Ashwaubenon, WI |
