| 1 | Mon Nov 6 | at Ohio State | L73-79 | 0-1 | .000 | - | | Value City Arena · Columbus, OH |
| 2 | Fri Nov 10 | at#25Illinois | L53-64 | 0-2 | .000 | - | | State Farm Center · Champaign, IL |
| 3 | Tue Nov 14 | vsBowling Green | W81-62 | 1-2 | .333 | - | | Athletics Center O'rena · Rochester, MI |
| 4 | Sun Nov 19 | atDrake | L77-85 | 1-3 | .250 | - | | The Knapp Center · Des Moines, IA |
| 5 | Mon Nov 20 | atLMU | W74-69 | 2-3 | .400 | - | | Gersten Pavilion · Los Angeles, CA |
| 6 | Tue Nov 21 | atMarshall | W78-71 | 3-3 | .500 | - | | Cam Henderson Center · Huntington, WV |
| 7 | Mon Nov 27 | atXavier | W78-76 | 4-3 | .571 | - | FS1 | Cintas Center · Cincinnati, OH |
| 8 | Wed Nov 29 | atDetroit Mercy | W65-50 | 5-3 | .625 | - | | Calihan Hall · Detroit, MI |
| 9 | Sat Dec 2 | vsPurdue FW | L77-98 | 5-4 | .556 | - | | Athletics Center O'rena · Rochester, MI |
| 10 | Wed Dec 6 | vsToledo | L68-69 | 5-5 | .500 | - | | Athletics Center O'rena · Rochester, MI |
| 11 | Fri Dec 8 | atE Michigan | W77-63 | 6-5 | .545 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 12 | Mon Dec 18 | atMichigan St | L62-79 | 6-6 | .500 | - | BTN | Breslin Center · East Lansing, MI |
| 13 | Wed Dec 20 | atDayton | L67-91 | 6-7 | .462 | - | | UD Arena · Dayton, OH |
| 14 | Thu Dec 28 | atCleveland St | L67-75 | 6-8 | .429 | - | | Wolstein Center · Cleveland, OH |
| 15 | Sun Dec 31 | atYoungstown St | W88-81 | 7-8 | .467 | - | | Beeghly Center · Youngstown, OH |
| 16 | Thu Jan 4 | vsMilwaukee | W100-95 | 8-8 | .500 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Sat Jan 6 | vsGreen Bay | W79-73 | 9-8 | .529 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Wed Jan 10 | vsN Kentucky | W70-65 (OT) | 10-8 | .556 | - | | Athletics Center O'rena · Rochester, MI |
| 19 | Sat Jan 13 | atIU Indy | W88-66 | 11-8 | .579 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 20 | Wed Jan 17 | vsYoungstown St | W70-67 | 12-8 | .600 | - | | Athletics Center O'rena · Rochester, MI |
| 21 | Thu Jan 25 | atGreen Bay | L59-69 | 12-9 | .571 | - | | Resch Center · Ashwaubenon, WI |
| 22 | Sat Jan 27 | atMilwaukee | W91-87 (2OT) | 13-9 | .591 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 23 | Thu Feb 1 | vsRobert Morris | W87-72 | 14-9 | .609 | - | | Athletics Center O'rena · Rochester, MI |
| 24 | Sat Feb 3 | vsCleveland St | W83-71 | 15-9 | .625 | - | | Athletics Center O'rena · Rochester, MI |
| 25 | Thu Feb 8 | atN Kentucky | L89-99 (OT) | 15-10 | .600 | - | | Truist Arena · Highland Heights, KY |
| 26 | Sat Feb 10 | atWright St | W74-60 | 16-10 | .615 | - | | Nutter Center · Dayton, OH |
| 27 | Wed Feb 14 | atPurdue FW | W71-63 | 17-10 | .630 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 28 | Sat Feb 17 | vsIU Indy | W107-59 | 18-10 | .643 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Thu Feb 22 | atRobert Morris | W63-43 | 19-10 | .655 | - | | UPMC Events Center · Moon Township, PA |
| 30 | Sun Feb 25 | vsWright St | L75-96 | 19-11 | .633 | - | | Athletics Center O'rena · Rochester, MI |
| 31 | Sat Mar 2 | vsDetroit Mercy | W75-70 | 20-11 | .645 | - | | Athletics Center O'rena · Rochester, MI |
| 32 | Thu Mar 7 | vsPurdue FW | W75-65 | 21-11 | .656 | - | | Athletics Center O'rena · Rochester, MI |
| 33 | Mon Mar 11 | vsCleveland St | W74-71 | 22-11 | .667 | - | ESPNU | Athletics Center O'rena · Rochester, MI |
| 34 | Tue Mar 12 | vsMilwaukee | W83-76 | 23-11 | .676 | - | ESPN | Athletics Center O'rena · Rochester, MI |
| 35 | Thu Mar 21 | at#3Kentucky | W80-76 | 24-11 | .686 | #14 | CBS | Rupp Arena · Lexington, KY |
| 36 | Sat Mar 23 | at#11NC State | L73-79 (OT) | 24-12 | .667 | #14 | TBS | PNC Arena · Raleigh, NC |
