| 1 | Mon Nov 7 | vs TBD | W92-27 | 1-0 | 1.000 | - | | Athletics Center O'rena · Rochester, MI |
| 2 | Fri Nov 11 | vsBowling Green | L82-87 | 1-1 | .500 | - | | Athletics Center O'rena · Rochester, MI |
| 3 | Sun Nov 13 | vsOklahoma St | L62-91 | 1-2 | .333 | - | | Athletics Center O'rena · Rochester, MI |
| 4 | Wed Nov 16 | atToledo | L90-112 | 1-3 | .250 | - | | Savage Arena · Toledo, OH |
| 5 | Sat Nov 19 | vsE Michigan | W92-90 (OT) | 2-3 | .400 | - | | Athletics Center O'rena · Rochester, MI |
| 6 | Fri Nov 25 | vsLong Beach St | L70-78 | 2-4 | .333 | - | | Athletics Center O'rena · Rochester, MI |
| 7 | Sat Nov 26 | atSan Jose St | L67-80 | 2-5 | .286 | - | | Provident Credit Union Event Center · San Jose, CA |
| 8 | Sun Nov 27 | atMissouri St | L64-76 | 2-6 | .250 | - | | Great Southern Bank Arena · Springfield, MO |
| 9 | Thu Dec 1 | atCleveland St | L64-80 | 2-7 | .222 | - | | Wolstein Center · Cleveland, OH |
| 10 | Sat Dec 3 | atPurdue FW | L73-79 (OT) | 2-8 | .200 | - | ESPNU | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 11 | Tue Dec 6 | atSyracuse | L66-95 | 2-9 | .182 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 12 | Sun Dec 18 | atBoise St | L57-77 | 2-10 | .167 | - | | ExtraMile Arena · Boise, ID |
| 13 | Wed Dec 21 | atMichigan St | L54-67 | 2-11 | .154 | - | BTN | Breslin Center · East Lansing, MI |
| 14 | Thu Dec 29 | vsMilwaukee | W83-61 | 3-11 | .214 | - | | Athletics Center O'rena · Rochester, MI |
| 15 | Sat Dec 31 | vsGreen Bay | W81-65 | 4-11 | .267 | - | | Athletics Center O'rena · Rochester, MI |
| 16 | Fri Jan 6 | atN Kentucky | W64-63 | 5-11 | .313 | - | | Truist Arena · Highland Heights, KY |
| 17 | Sun Jan 8 | atWright St | W75-73 | 6-11 | .353 | - | | Nutter Center · Dayton, OH |
| 18 | Thu Jan 12 | vsRobert Morris | W69-65 | 7-11 | .389 | - | | Athletics Center O'rena · Rochester, MI |
| 19 | Sat Jan 14 | vsYoungstown St | L69-85 | 7-12 | .368 | - | | Athletics Center O'rena · Rochester, MI |
| 20 | Thu Jan 19 | atIU Indy | W83-77 (OT) | 8-12 | .400 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Mon Jan 23 | atDetroit Mercy | W76-67 | 9-12 | .429 | - | | Calihan Hall · Detroit, MI |
| 22 | Fri Jan 27 | atYoungstown St | L73-77 | 9-13 | .409 | - | ESPN2 | Beeghly Center · Youngstown, OH |
| 23 | Sun Jan 29 | atRobert Morris | L63-68 | 9-14 | .391 | - | | UPMC Events Center · Moon Township, PA |
| 24 | Thu Feb 2 | vsPurdue FW | L73-82 | 9-15 | .375 | - | | Athletics Center O'rena · Rochester, MI |
| 25 | Sat Feb 4 | vsCleveland St | W92-89 (OT) | 10-15 | .400 | - | | Athletics Center O'rena · Rochester, MI |
| 26 | Thu Feb 9 | atGreen Bay | W59-47 | 11-15 | .423 | - | | Resch Center · Ashwaubenon, WI |
| 27 | Sat Feb 11 | atMilwaukee | L77-80 (OT) | 11-16 | .407 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Wed Feb 15 | vsIU Indy | W85-81 | 12-16 | .429 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Fri Feb 17 | vsDetroit Mercy | L74-96 | 12-17 | .414 | - | | Athletics Center O'rena · Rochester, MI |
| 30 | Thu Feb 23 | vsWright St | W75-68 | 13-17 | .433 | - | | Athletics Center O'rena · Rochester, MI |
| 31 | Sat Feb 25 | vsN Kentucky | L69-78 | 13-18 | .419 | - | | Athletics Center O'rena · Rochester, MI |
| 32 | Thu Mar 2 | atN Kentucky | L74-81 | 13-19 | .406 | - | | Truist Arena · Highland Heights, KY |
