| 1 | Wed Nov 25 | at Xavier | L49-101 | 0-1 | .000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 2 | Thu Nov 26 | vsToledo | L53-80 | 0-2 | .000 | - | | Cintas Center · Cincinnati, OH |
| 3 | Fri Nov 27 | atBradley | L60-74 | 0-3 | .000 | - | | Cintas Center · Cincinnati, OH |
| 4 | Sun Nov 29 | at25Michigan | L71-81 (OT) | 0-4 | .000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 5 | Tue Dec 1 | atPurdue | L50-93 | 0-5 | .000 | - | BTN | Mackey Arena · West Lafayette, IN |
| 6 | Sat Dec 5 | atOklahoma St | L71-84 | 0-6 | .000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 7 | Sun Dec 13 | at4Michigan St | L91-109 | 0-7 | .000 | - | FS1 | Breslin Center · East Lansing, MI |
| 8 | Sat Dec 19 | atUIC | L72-74 | 0-8 | .000 | - | | Credit Union 1 Arena · Chicago, IL |
| 9 | Sun Dec 20 | atUIC | L73-90 | 0-9 | .000 | - | | Credit Union 1 Arena · Chicago, IL |
| 10 | Sat Dec 26 | atDetroit Mercy | W77-75 (OT) | 1-9 | .100 | - | | Calihan Hall · Detroit, MI |
| 11 | Sun Dec 27 | atDetroit Mercy | W83-80 | 2-9 | .182 | - | | Calihan Hall · Detroit, MI |
| 12 | Fri Jan 1 | vsWright St | L51-90 | 2-10 | .167 | - | | Athletics Center O'rena · Rochester, MI |
| 13 | Sat Jan 2 | vsWright St | W81-71 | 3-10 | .231 | - | | Athletics Center O'rena · Rochester, MI |
| 14 | Fri Jan 8 | atGreen Bay | L81-84 (OT) | 3-11 | .214 | - | | Resch Center · Ashwaubenon, WI |
| 15 | Sat Jan 9 | atGreen Bay | L78-87 | 3-12 | .200 | - | | Resch Center · Ashwaubenon, WI |
| 16 | Fri Jan 15 | vsYoungstown St | W82-65 | 4-12 | .250 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Sat Jan 16 | vsYoungstown St | W81-74 | 5-12 | .294 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Fri Jan 22 | vsDetroit Mercy | W86-81 | 6-12 | .333 | - | | Athletics Center O'rena · Rochester, MI |
| 19 | Sat Jan 23 | vsDetroit Mercy | L72-82 | 6-13 | .316 | - | | Athletics Center O'rena · Rochester, MI |
| 20 | Fri Jan 29 | atPurdue FW | W81-66 | 7-13 | .350 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 21 | Sat Jan 30 | atPurdue FW | W82-75 | 8-13 | .381 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 22 | Fri Feb 5 | vsCleveland St | L72-80 | 8-14 | .364 | - | | Athletics Center O'rena · Rochester, MI |
| 23 | Sat Feb 6 | vsCleveland St | L78-80 | 8-15 | .348 | - | | Athletics Center O'rena · Rochester, MI |
| 24 | Fri Feb 12 | atRobert Morris | L82-88 (2OT) | 8-16 | .333 | - | | UPMC Events Center · Moon Township, PA |
| 25 | Sat Feb 13 | atRobert Morris | W86-81 | 9-16 | .360 | - | | UPMC Events Center · Moon Township, PA |
| 26 | Fri Feb 19 | atMilwaukee | W85-81 | 10-16 | .385 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 27 | Sat Feb 20 | atMilwaukee | L87-89 (2OT) | 10-17 | .370 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Tue Mar 2 | vsYoungstown St | W87-83 (OT) | 11-17 | .393 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Mon Mar 8 | vsN Kentucky | W69-58 | 12-17 | .414 | - | ESPN2 | Indiana Farmers Coliseum · Indianapolis, IN |
| 30 | Tue Mar 9 | atCleveland St | L69-80 | 12-18 | .400 | - | ESPN | Indiana Farmers Coliseum · Indianapolis, IN |
