| 1 | Mon Nov 4 | vs TBD | W75-52 | 1-0 | 1.000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 2 | Wed Nov 6 | atBoise St | L43-87 | 1-1 | .500 | - | | ExtraMile Arena · Boise, ID |
| 3 | Wed Nov 13 | atIllinois | L54-66 | 1-2 | .333 | - | BTN | State Farm Center · Champaign, IL |
| 4 | Sat Nov 16 | at#1Kansas | L57-78 | 1-3 | .250 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 5 | Thu Nov 21 | vsE Michigan | L64-68 | 1-4 | .200 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 6 | Sat Nov 30 | atToledo | W85-52 | 2-4 | .333 | - | ESPN+ | Savage Arena · Toledo, OH |
| 7 | Thu Dec 5 | vsWright St | W66-64 | 3-4 | .429 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 8 | Sat Dec 7 | atYoungstown St | L50-66 | 3-5 | .375 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 9 | Tue Dec 17 | vs#20Michigan St | L58-77 | 3-6 | .333 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 10 | Thu Dec 19 | atCleveland St | L75-92 | 3-7 | .300 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 11 | Sun Dec 22 | vsLoyola Chicago | W72-71 | 4-7 | .364 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 12 | Mon Dec 23 | vsOregon St | L74-80 (OT) | 4-8 | .333 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 13 | Wed Dec 25 | atHawai'i | L70-73 (OT) | 4-9 | .308 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 14 | Mon Dec 30 | at#23Arkansas | L62-92 | 4-10 | .286 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 15 | Thu Jan 2 | vsMilwaukee | W65-49 | 5-10 | .333 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 16 | Sat Jan 4 | vsRobert Morris | L71-79 | 5-11 | .313 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 17 | Thu Jan 9 | atWright St | L62-66 | 5-12 | .294 | - | ESPN+ | Nutter Center · Dayton, OH |
| 18 | Sat Jan 11 | atN Kentucky | W68-53 | 6-12 | .333 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 19 | Wed Jan 15 | vsIU Indy | W72-59 | 7-12 | .368 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 20 | Sat Jan 18 | atDetroit Mercy | W65-59 | 8-12 | .400 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 21 | Wed Jan 22 | vsPurdue FW | W76-72 | 9-12 | .429 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 25 | atRobert Morris | L71-73 | 9-13 | .409 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 23 | Thu Jan 30 | vsGreen Bay | W68-54 | 10-13 | .435 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 24 | Sat Feb 1 | vsN Kentucky | L75-84 | 10-14 | .417 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 25 | Thu Feb 6 | vsYoungstown St | L75-84 | 10-15 | .400 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 26 | Wed Feb 12 | atIU Indy | W82-67 | 11-15 | .423 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 27 | Sun Feb 16 | vsDetroit Mercy | W93-83 (OT) | 12-15 | .444 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 28 | Fri Feb 21 | atPurdue FW | L66-80 | 12-16 | .429 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 29 | Sun Feb 23 | vsCleveland St | W91-86 (OT) | 13-16 | .448 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 30 | Thu Feb 27 | atMilwaukee | L66-71 | 13-17 | .433 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 31 | Sat Mar 1 | atGreen Bay | W87-84 (OT) | 14-17 | .452 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 32 | Tue Mar 4 | vsGreen Bay | W96-72 | 15-17 | .469 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 33 | Thu Mar 6 | atMilwaukee | W72-64 | 16-17 | .485 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 34 | Mon Mar 10 | atRobert Morris | L76-79 (OT) | 16-18 | .471 | - | ESPNU | Indiana Farmers Coliseum · Indianapolis, IN |
