| 1 | Mon Nov 3 | at 7Michigan | L78-121 | 0-1 | .000 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 2 | Fri Nov 7 | at1Purdue | L77-87 | 0-2 | .000 | - | Peacock | Mackey Arena · West Lafayette, IN |
| 3 | Wed Nov 12 | at1Houston | L45-78 | 0-3 | .000 | - | ESPN+ | Fertitta Center · Houston, TX |
| 4 | Sat Nov 15 | vsTBD | W113-47 | 1-3 | .250 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 5 | Mon Nov 17 | atUCF | L83-87 | 1-4 | .200 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 6 | Fri Nov 21 | atE Michigan | L91-97 | 1-5 | .167 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 7 | Mon Nov 24 | atLamar | W83-68 | 2-5 | .286 | - | ESPN+ | Dahlberg Arena · Missoula, MT |
| 8 | Tue Nov 25 | atMontana | W95-87 | 3-5 | .375 | - | ESPN+ | Dahlberg Arena · Missoula, MT |
| 9 | Wed Dec 3 | vsPurdue FW | W101-92 | 4-5 | .444 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 10 | Sat Dec 6 | vsToledo | W98-97 | 5-5 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 11 | Sat Dec 13 | atNorthern Iowa | L63-75 | 5-6 | .455 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 12 | Wed Dec 17 | atN Kentucky | W82-77 | 6-6 | .500 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 13 | Sat Dec 20 | at9Michigan St | L70-79 | 6-7 | .462 | - | BTN | Breslin Center · East Lansing, MI |
| 14 | Mon Dec 29 | atWright St | L73-88 | 6-8 | .429 | - | ESPN+ | Nutter Center · Dayton, OH |
| 15 | Thu Jan 1 | atYoungstown St | W85-83 | 7-8 | .467 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 16 | Sun Jan 4 | vsRobert Morris | W96-73 | 8-8 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 17 | Fri Jan 9 | vsCleveland St | W97-74 | 9-8 | .529 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | vsWright St | L84-94 | 9-9 | .500 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 19 | Thu Jan 15 | atMilwaukee | W73-60 | 10-9 | .526 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sun Jan 18 | atGreen Bay | W88-63 | 11-9 | .550 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 21 | Wed Jan 21 | vsIU Indy | L85-103 | 11-10 | .524 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 24 | atDetroit Mercy | W95-87 | 12-10 | .545 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 23 | Wed Jan 28 | atPurdue FW | W74-65 | 13-10 | .565 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Sun Feb 1 | vsN Kentucky | W76-65 | 14-10 | .583 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 25 | Wed Feb 4 | atCleveland St | L78-91 | 14-11 | .560 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 26 | Thu Feb 12 | vsYoungstown St | L82-86 | 14-12 | .538 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 27 | Sun Feb 15 | atRobert Morris | L69-93 | 14-13 | .519 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 28 | Fri Feb 20 | vsGreen Bay | L68-73 | 14-14 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 29 | Sun Feb 22 | vsMilwaukee | W81-70 | 15-14 | .517 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 30 | Wed Feb 25 | atIU Indy | W86-74 | 16-14 | .533 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 28 | vsDetroit Mercy | L89-95 | 16-15 | .516 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
