| 1 | Mon Nov 3 | at #7Michigan | 8:30 PM | 27-10 | .730 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 2 | Fri Nov 7 | at#1Purdue | TBD | 24-12 | .667 | - | Peacock | Mackey Arena · West Lafayette, IN |
| 3 | Wed Nov 12 | at#2Houston | 8:00 PM | 35-5 | .875 | - | ESPN+ | Fertitta Center · Houston, TX |
| 4 | Sat Nov 15 | vsTBD | 3:00 PM | 0-0 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 5 | Mon Nov 17 | atUCF | 7:00 PM | 20-17 | .541 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 6 | Fri Nov 21 | atE Michigan | 6:30 PM | 16-16 | .500 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 7 | Mon Nov 24 | atLamar | 4:00 PM | 20-13 | .606 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 8 | Tue Nov 25 | atMontana | 9:00 PM | 25-10 | .714 | - | ESPN+ | Dahlberg Arena · Missoula, MT |
| 9 | Wed Dec 3 | vsPurdue FW | 7:00 PM | 19-13 | .594 | - | | Athletics Center O'rena · Rochester, MI |
| 10 | Sat Dec 6 | vsToledo | 3:00 PM | 18-15 | .545 | - | | Athletics Center O'rena · Rochester, MI |
| 11 | Sat Dec 13 | atNorthern Iowa | TBD | 20-13 | .606 | - | | McLeod Center · Cedar Falls, IA |
| 12 | Wed Dec 17 | atN Kentucky | 7:00 PM | 17-16 | .515 | - | | Truist Arena · Highland Heights, KY |
| 13 | Sat Dec 20 | at#22Michigan St | TBD | 30-7 | .811 | - | | Breslin Center · East Lansing, MI |
| 14 | Mon Dec 29 | atWright St | TBD | 15-18 | .455 | - | | Nutter Center · Dayton, OH |
| 15 | Thu Jan 1 | atYoungstown St | 1:00 PM | 21-13 | .618 | - | | Beeghly Center · Youngstown, OH |
| 16 | Sun Jan 4 | vsRobert Morris | 3:00 PM | 26-9 | .743 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Fri Jan 9 | vsCleveland St | 7:00 PM | 23-13 | .639 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | vsWright St | 3:00 PM | 15-18 | .455 | - | | Athletics Center O'rena · Rochester, MI |
| 19 | Thu Jan 15 | atMilwaukee | TBD | 21-11 | .656 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sun Jan 18 | atGreen Bay | 2:00 PM | 4-28 | .125 | - | | Resch Center · Ashwaubenon, WI |
| 21 | Wed Jan 21 | vsIU Indy | 7:00 PM | 10-22 | .313 | - | | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 24 | atDetroit Mercy | 3:00 PM | 8-24 | .250 | - | | Calihan Hall · Detroit, MI |
| 23 | Wed Jan 28 | atPurdue FW | 7:00 PM | 19-13 | .594 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Sun Feb 1 | vsN Kentucky | 3:00 PM | 17-16 | .515 | - | | Athletics Center O'rena · Rochester, MI |
| 25 | Wed Feb 4 | atCleveland St | 7:00 PM | 23-13 | .639 | - | | Wolstein Center · Cleveland, OH |
| 26 | Thu Feb 12 | vsYoungstown St | 7:00 PM | 21-13 | .618 | - | | Athletics Center O'rena · Rochester, MI |
| 27 | Sun Feb 15 | atRobert Morris | 2:00 PM | 26-9 | .743 | - | | UPMC Events Center · Moon Township, PA |
| 28 | Fri Feb 20 | vsGreen Bay | 7:00 PM | 4-28 | .125 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Sun Feb 22 | vsMilwaukee | 3:00 PM | 21-11 | .656 | - | | Athletics Center O'rena · Rochester, MI |
| 30 | Wed Feb 25 | atIU Indy | 6:30 PM | 10-22 | .313 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 28 | vsDetroit Mercy | 3:00 PM | 8-24 | .250 | - | | Athletics Center O'rena · Rochester, MI |
