| 3 | Wed Nov 12 | at #2Houston | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Fertitta Center · Houston, TX |
| 4 | Sat Nov 15 | vsTBD | 3:00 PM | 0-0 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 5 | Mon Nov 17 | atUCF | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 6 | Fri Nov 21 | atE Michigan | 6:30 PM | 1-0 | 1.000 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 7 | Mon Nov 24 | vsLamar | 4:00 PM | 1-0 | 1.000 | - | ESPN+ | Dahlberg Arena · Missoula, MT |
| 8 | Tue Nov 25 | atMontana | 9:00 PM | 2-0 | 1.000 | - | ESPN+ | Dahlberg Arena · Missoula, MT |
| 9 | Wed Dec 3 | vsPurdue FW | 7:00 PM | 0-2 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 10 | Sat Dec 6 | vsToledo | 3:00 PM | 0-1 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 11 | Sat Dec 13 | atNorthern Iowa | 6:00 PM | 1-0 | 1.000 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 12 | Wed Dec 17 | atN Kentucky | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 13 | Sat Dec 20 | at#22Michigan St | 12:00 PM | 1-0 | 1.000 | - | | Breslin Center · East Lansing, MI |
| 14 | Mon Dec 29 | atWright St | 7:00 PM | 1-1 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 15 | Thu Jan 1 | atYoungstown St | 1:00 PM | 1-1 | .500 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 16 | Sun Jan 4 | vsRobert Morris | 3:00 PM | 1-1 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 17 | Fri Jan 9 | vsCleveland St | 7:00 PM | 1-1 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 18 | Sun Jan 11 | vsWright St | 3:00 PM | 1-1 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 19 | Thu Jan 15 | atMilwaukee | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sun Jan 18 | atGreen Bay | 2:00 PM | 0-2 | .000 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 21 | Wed Jan 21 | vsIU Indy | 7:00 PM | 0-2 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 22 | Sat Jan 24 | atDetroit Mercy | 3:00 PM | 0-2 | .000 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 23 | Wed Jan 28 | atPurdue FW | 7:00 PM | 0-2 | .000 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Sun Feb 1 | vsN Kentucky | 3:00 PM | 1-0 | 1.000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 25 | Wed Feb 4 | atCleveland St | 7:00 PM | 1-1 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 26 | Thu Feb 12 | vsYoungstown St | 7:00 PM | 1-1 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 27 | Sun Feb 15 | atRobert Morris | 2:00 PM | 1-1 | .500 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 28 | Fri Feb 20 | vsGreen Bay | 7:00 PM | 0-2 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 29 | Sun Feb 22 | vsMilwaukee | 3:00 PM | 1-0 | 1.000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 30 | Wed Feb 25 | atIU Indy | 6:30 PM | 0-2 | .000 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 31 | Sat Feb 28 | vsDetroit Mercy | 3:00 PM | 0-2 | .000 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
