| 1 | Tue Nov 9 | at West Virginia | L53-60 | 0-1 | .000 | - | | WVU Coliseum · Morgantown, WV |
| 2 | Fri Nov 12 | atOklahoma St | W56-55 | 1-1 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Wed Nov 17 | vsToledo | W80-59 | 2-1 | .667 | - | | Athletics Center O'rena · Rochester, MI |
| 4 | Fri Nov 19 | at#14Alabama | L59-86 | 2-2 | .500 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 5 | Mon Nov 22 | atVermont | W63-61 | 3-2 | .600 | - | | Patrick Gymnasium · Burlington, VT |
| 6 | Tue Nov 23 | atRice | W76-73 | 4-2 | .667 | - | | Tudor Fieldhouse · Houston, TX |
| 7 | Wed Nov 24 | vsDelaware | W81-73 | 5-2 | .714 | - | | Athletics Center O'rena · Rochester, MI |
| 8 | Thu Dec 2 | atUIC | W81-77 | 6-2 | .750 | - | | Credit Union 1 Arena · Chicago, IL |
| 9 | Sat Dec 4 | atIU Indy | W78-45 | 7-2 | .778 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 10 | Tue Dec 7 | atBowling Green | L72-73 | 7-3 | .700 | - | | Stroh Center · Bowling Green, OH |
| 11 | Tue Dec 21 | vs#11Michigan St | L78-90 | 7-4 | .636 | - | | Athletics Center O'rena · Rochester, MI |
| 12 | Thu Dec 30 | vsRobert Morris | W79-61 | 8-4 | .667 | - | | Athletics Center O'rena · Rochester, MI |
| 13 | Sat Jan 1 | vsYoungstown St | W87-72 | 9-4 | .692 | - | | Athletics Center O'rena · Rochester, MI |
| 15 | Fri Jan 7 | vsTBD | W108-40 | 10-4 | .714 | - | | Athletics Center O'rena · Rochester, MI |
| 16 | Sun Jan 9 | vsMilwaukee | W86-65 | 11-4 | .733 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Thu Jan 13 | atCleveland St | W70-65 | 12-4 | .750 | - | | Wolstein Center · Cleveland, OH |
| 18 | Sat Jan 15 | atPurdue FW | W76-68 | 13-4 | .765 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 19 | Thu Jan 20 | atMilwaukee | L78-88 | 13-5 | .722 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sat Jan 22 | atGreen Bay | W68-61 | 14-5 | .737 | - | | Resch Center · Ashwaubenon, WI |
| 21 | Mon Jan 24 | vsTBD | W104-61 | 15-5 | .750 | - | | Athletics Center O'rena · Rochester, MI |
| 23 | Sat Jan 29 | vsUIC | W81-74 | 16-5 | .762 | - | | Athletics Center O'rena · Rochester, MI |
| 24 | Thu Feb 3 | atN Kentucky | PPD | 20-12 | .625 | - | | Truist Arena · Highland Heights, KY |
| 25 | Fri Feb 4 | atN Kentucky | L78-87 (OT) | 16-6 | .727 | - | | Truist Arena · Highland Heights, KY |
| 26 | Sat Feb 5 | atWright St | L64-75 | 16-7 | .696 | - | | Nutter Center · Dayton, OH |
| 27 | Wed Feb 9 | atYoungstown St | L71-78 | 16-8 | .667 | - | | Beeghly Center · Youngstown, OH |
| 28 | Fri Feb 11 | atRobert Morris | W71-68 | 17-8 | .680 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Sun Feb 13 | vsDetroit Mercy | W75-59 | 18-8 | .692 | - | | Athletics Center O'rena · Rochester, MI |
| 30 | Fri Feb 18 | vsWright St | L74-78 | 18-9 | .667 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 31 | Sun Feb 20 | vsN Kentucky | L66-71 | 18-10 | .643 | - | | Athletics Center O'rena · Rochester, MI |
| 32 | Thu Feb 24 | vsPurdue FW | L70-81 | 18-11 | .621 | - | | Athletics Center O'rena · Rochester, MI |
| 33 | Sat Feb 26 | vsCleveland St | W65-57 | 19-11 | .633 | - | | Athletics Center O'rena · Rochester, MI |
| 34 | Tue Mar 1 | vsIU Indy | W70-58 | 20-11 | .645 | - | | Athletics Center O'rena · Rochester, MI |
| 35 | Thu Mar 3 | atWright St | L63-75 | 20-12 | .625 | - | | Nutter Center · Dayton, OH |
